FBL10 Antibody (5G1): sc-293279

FBL10 Antibody (5G1) is a mouse monoclonal IgG2b kappa light chain antibody that detects the FBL10 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FBL10 antibody (5G1) is available as the non-conjugated format. FBXL10, also known as Fbl10, CXXC2, PCCX2, KDM2B, JEMMA, or JHDM1B, is a nuclear protein characterized by its unique structure, which includes one F-box domain, a CXXC-type zinc finger, one JMJC domain, four leucine-rich repeats, and one PHD-type zinc finger. This intricate structure is crucial as FBXL10 functions effectively as a component of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex, facilitating substrate recognition and recruitment for ubiquitination. Additionally, FBXL10′s role as a dimethylation-specific demethylase, where FBXL10 binds iron as a cofactor to demethylate lysine-36 of Histone H3, underscores its importance in regulating the histone code, which is vital for gene expression and chromatin dynamics. FBL10 (5G1) antibody accurately detects this multifaceted protein, making FBL10 (5G1) monoclonal antibody an essential tool for researchers studying epigenetic regulation and cellular processes in human samples.

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FBL10 Antibody (5G1) References:

1. A family of mammalian F-box proteins.  |  Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
2. PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis.  |  Fujino, T., et al. 2000. Biochem Biophys Res Commun. 271: 305-10. PMID: 10799292
3. Systematic analysis and nomenclature of mammalian F-box proteins.  |  Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
4. Histone demethylation by a family of JmjC domain-containing proteins.  |  Tsukada, Y., et al. 2006. Nature. 439: 811-6. PMID: 16362057
5. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice.  |  Suzuki, T., et al. 2006. EMBO J. 25: 3422-31. PMID: 16858412
6. The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun.  |  Koyama-Nasu, R., et al. 2007. Nat Cell Biol. 9: 1074-80. PMID: 17704768
7. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.  |  Frescas, D., et al. 2007. Nature. 450: 309-13. PMID: 17994099
8. Secondary DNA structure formation for Hoxb9 promoter and identification of its specific binding protein.  |  Yamagishi, T., et al. 2008. Nucleic Acids Res. 36: 1965-75. PMID: 18276649
9. Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.  |  Fukuda, T., et al. 2011. Mol Cell Neurosci. 46: 614-24. PMID: 21220025
10. FBXL10 protects Polycomb-bound genes from hypermethylation.  |  Boulard, M., et al. 2015. Nat Genet. 47: 479-85. PMID: 25848754
11. FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC β2 pathway.  |  Yin, L., et al. 2019. J Cell Mol Med. 23: 2558-2567. PMID: 30701683
12. FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα.  |  Yang, Y., et al. 2021. Cancer Lett. 502: 108-119. PMID: 33450359

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FBL10 Antibody (5G1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FBL10 Antibody (5G1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FBL10 Antibody (5G1) Specifications

Alternate Product Name: FBL10

Product Clone Name: 5G1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 457-555

Epitope Target: FBL10

Epitope Species: human

Product Reactivity/Detection: FBL10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FBL10 Antibody (5G1): N/A