FAT1 Antibody (1634CT464.1.9): sc-517329

FAT1 Antibody (1634CT464.1.9) is a mouse monoclonal IgG1 antibody that detects FAT1 protein of human origin by western blotting (WB). Anti-FAT1 antibody (1634CT464.1.9) is available as a non-conjugated format. FAT1, a member of the Cadherin superfamily, plays a crucial role in regulating cell growth and planar polarity, acting as a tumor suppressor. FAT1 functions as a proximal element in a pathway that influences both cellular polarity and directed actin-dependent motility. FAT1 is localized at the leading edge of lamellipodia, filopodia, and microspike tips, where FAT1 interacts directly with Ena/VASP proteins to modulate the actin polymerization complex. Such interactions maintain structural integrity and functionality of cells, especially during migration and proliferation. FAT1 expression increases significantly in vascular smooth muscle cells following arterial injury or growth factor stimulation, highlighting FAT1′s role in vascular remodeling. FAT1 has been implicated in various psychiatric disorders, suggesting broader pathophysiological implications.

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FAT1 Antibody (1634CT464.1.9) References:

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