Molecular structure of Farnesylthioacetic Acid (FTA), CAS Number: 135784-48-4
Farnesylthioacetic Acid (FTA) (CAS 135784-48-4)
Application:
Farnesylthioacetic Acid (FTA) is an inhibitor of Ca2+ influx through non-voltage-gated Ca2+ channels
CAS Number:
135784-48-4
Molecular Weight:
296.5
Molecular Formula:
C17H28O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FTA has shown potent and specifc inhibition of methyl esterification of farnesylated and geranylgeranylated proteins. It has inhibited Ca2+ influx through non-voltage-gated Ca2+ channels. FTA also has the property to be a TRPA1 agonist.
Farnesylthioacetic Acid (FTA) (CAS 135784-48-4) References
- Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton. | Rosado, JA. and Sage, SO. 2000. Biochem J. 347 Pt 1: 183-92. PMID: 10727417
- Regulation of plasma membrane Ca2+-ATPase by small GTPases and phosphoinositides in human platelets. | Rosado, JA. and Sage, SO. 2000. J Biol Chem. 275: 19529-35. PMID: 10748016
- Identification of prenylcysteine carboxymethyltransferase in bovine adrenal chromaffin cells. | De Busser, HM., et al. 2000. Int J Biochem Cell Biol. 32: 1007-16. PMID: 11084380
- Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs. | Lamango, NS., et al. 2003. Pharmacol Biochem Behav. 76: 433-42. PMID: 14643842
- Dual effect of hydrogen peroxide on store-mediated calcium entry in human platelets. | Redondo, PC., et al. 2004. Biochem Pharmacol. 67: 1065-76. PMID: 15006543
- Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. | Pérez-Sala, D., et al. 1992. Biochem J. 284 (Pt 3): 835-40. PMID: 1622400
- A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. | Volker, C., et al. 1991. FEBS Lett. 295: 189-94. PMID: 1765152
- Activation of TRPA1 by farnesyl thiosalicylic acid. | Maher, M., et al. 2008. Mol Pharmacol. 73: 1225-34. PMID: 18171730
- Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. J. Membrane Biol. 27:283. | Uyesaka, N. 1977. J Membr Biol. 30: 403. PMID: 190405
- Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem death. | Chan, SH., et al. 2011. Br J Pharmacol. 164: 2015-28. PMID: 21615729
- Inhibition of capacitative Ca2+ entry into cells by farnesylcysteine analogs. | Xu, Y., et al. 1996. Mol Pharmacol. 50: 1495-501. PMID: 8967970
- Pancreatic exocrine secretion is blocked by inhibitors of methylation. | Capdevila, A., et al. 1997. Arch Biochem Biophys. 345: 47-55. PMID: 9281310
- Regulation by GTPgammaS of protein carboxylmethyltransferase activity in kidney brush border membranes. | Desrosiers, RR. and Béliveau, R. 1998. Arch Biochem Biophys. 351: 149-58. PMID: 9514644
Inhibitor of:
Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Farnesylthioacetic Acid (FTA), 5 mg | sc-200845 | 5 mg | $72.00 | |||
Farnesylthioacetic Acid (FTA), 25 mg | sc-200845A | 25 mg | $272.00 |