Farnesyl pyrophosphate ammonium salt, in methanol CAS: 13058-04-3
MF: C15H25O7P2•3NH4
MW: 433.42
An isoprenoid farnesyl donor.

Farnesyl pyrophosphate ammonium salt, in methanol (CAS 13058-04-3)

Farnesyl pyrophosphate ammonium salt, in methanol | CAS 13058-04-3 is rated 5.0 out of 5 by 1.
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Synonym: FPP.3NH4; 3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt
Application: An isoprenoid farnesyl donor
CAS Number: 13058-04-3
Molecular Weight: 433.42
Molecular Formula: C15H25O7P23NH4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Farnesyl pyrophosphate ammonium salt, in methanol, is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase. It is also used for prenylation of several low molecular mass G proteins, including Ras. FPP has been shown to negate the inhibitory effects of cell growth for cells grown in high glucose conditions as well as to reverse the growth inhibitory effects of statins on variant human embryonic stem cells and cancer cells. FPP has also been detected in Alzheimer's patients brains in elevated levels. Farnesyl pyrophosphate ammonium salt is an inhibitor of P2Y12. Concentration: ~ 1 mg/ml in methanol: 10 mM ammonium hydroxide (7:3).


References

1. Pompliano, D.L. 1992. Biochemistry. 31(15): 3800-3807. PMID: 1567835 2. Reiss, Y. 1992. J. Biol. Chem. 267(9): 6403-6408. PMID: 1556143 3. Gauthaman, K. 2009. Br. J. Pharmacol. 157(6): 962-973. PMID: 19438511 4. Ye, Y. 2009. FEBS Lett. 583(18): 2997-30

Formulation :
~ 1 mg/ml in methanol: 10 mM ammonium hydroxide (7:3)
Physical State :
Liquid
Storage :
Store at -20° C
Boiling Point :
64° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1230, Class 3 (6.1), Packing group II
PubChem CID :
71299715
SMILES :
CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C.N.N.N

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Rated 5 out of 5 by from Hooff Hooff, GP. et al. (PubMed 22692983) reported that brain isoprenoids Farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. -SCBT Publication Review
Date published: 2015-02-21
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