FANCE Antibody (2346C5a): sc-130638
- FANCE Antibody (2346C5a) is a mouse monoclonal IgG2b provided at 100 µg/ml
- raised against a recombinant protein corresponding an internal region of FANCE of human origin
- recommended for detection of FANCE of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FANCE Antibody (2346C5a). This work is in progress.
FANCE Antibody (2346C5a) is a mouse monoclonal IgG2b antibody that detects FANCE in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). FANCE plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for maintaining genomic stability and repairing DNA cross-links. FANCE is involved in the monoubiquitination of FANCD2, a key step that facilitates the recruitment of repair proteins to sites of DNA damage, thereby preventing chromosomal instability and the development of cancer. Located on chromosome 6p22-p21, the FANCE gene encodes a 536-amino acid protein that features two potential nuclear localization signals, indicating an important function within the nucleus. The interaction of FANCE with other FA proteins, such as FANCA and FANCC, underscores FANCE′s significance in the cooperative network that orchestrates DNA repair processes. Anti-FANCE antibody (2346C5a) enables researchers to gain insights into the molecular mechanisms underlying Fanconi anemia and its associated pathologies, making this antibody a valuable tool for studies focused on DNA repair and cellular response to genotoxic stress.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCE Antibody (2346C5a) | sc-130638 | 100 µg/ml | $339.00 |