FANCC Antibody (6E7): sc-293308
- FANCC Antibody (6E7) is a mouse monoclonal IgG2b κ FANCC antibody provided at 100 µg/ml
- raised against amino acids 1-100 of FANCC of human origin
- recommended for detection of FANCC of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FANCC Antibody (6E7). This work is in progress.
FANCC Antibody (6E7) is a mouse monoclonal IgG2b kappa light chain antibody that detects FANCC protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FANCC antibody (6E7) is available as the non-conjugated form. FANCC protein plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for DNA repair and maintaining genomic stability. Mutations in FANCC gene can lead to Fanconi anemia, an autosomal recessive disorder characterized by bone marrow failure, developmental abnormalities, and increased susceptibility to cancer due to chromosomal instability. FANCC protein is located in both cytoplasm and nucleus, and expression is regulated throughout the cell cycle, peaking during M-phase, which is vital for function in DNA repair during cell division. Furthermore, FANCC interacts with other proteins in FA pathway, such as FANCA, to form a nuclear complex critical for repair of DNA interstrand cross-links. Interaction of FANCC with spectrin II protein enhances this complex′s stability, underscoring importance of protein-protein interactions in cellular processes. Additionally, in hematopoietic cells with mutant FANCC, protein kinase R (PKR) is constitutively activated, leading to increased sensitivity to inflammatory cytokines like interferon-gamma and tumor necrosis factor-alpha, which highlights FANCC′s role in regulating cellular responses to stress.
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FANCC Antibody (6E7) References:
- A patient-derived mutant form of the Fanconi anemia protein, FANCA, is defective in nuclear accumulation. | Kupfer, G., et al. 1999. Exp Hematol. 27: 587-93. PMID: 10210316
- Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. | McMahon, LW., et al. 1999. J Biol Chem. 274: 32904-8. PMID: 10551855
- Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain. | Kruyt, FA., et al. 1999. J Biol Chem. 274: 34212-8. PMID: 10567393
- A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. | Hoatlin, ME., et al. 1999. Blood. 94: 3737-47. PMID: 10572087
- Posttranscriptional cell cycle-dependent regulation of human FANCC expression. | Heinrich, MC., et al. 2000. Blood. 95: 3970-7. PMID: 10845936
- The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. | Pang, Q., et al. 2000. Mol Cell Biol. 20: 4724-35. PMID: 10848598
- Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA. | Pang, Q., et al. 2001. Blood. 97: 1644-52. PMID: 11238103
- Functional correction of FA-C cells with FANCC suppresses the expression of interferon gamma-inducible genes. | Fagerlie, SR., et al. 2001. Blood. 97: 3017-24. PMID: 11342426
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCC Antibody (6E7) | sc-293308 | 100 µg/ml | $316.00 |