Fananserin CAS: 127625-29-0
MF: C23H24FN3O2S
MW: 425.52
An antagonist of 5-HT2A.

Fananserin (CAS 127625-29-0)

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Synonym: RP 62203
Application: An antagonist of 5-HT2A
CAS Number: 127625-29-0
Purity: ≥99%
Molecular Weight: 425.52
Molecular Formula: C23H24FN3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fananserin is a potent 5-HT2A and D4 receptor (dopamine D4) antagonist, with efficacy against histamine H1, α1 and 5HT having Ki values of 0.26, 2.93, 25, 38, 70, and 726 nM, respectively. Fananserin shows very modest efficacy towards Dopamine D2 receptors with a Ki value of 726 nM.


References

1. Malleron, J.L., et al. 1991. J. Med. Chem. 34: 2477-2483.
2. Doble, A., et al. 1992. Br. J. Pharmacol. 105: 27-36.
3. Heuillet, E., et al. 1996. Eur. J. Pharmacol. 314: 229-233.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
238.16° C (Predicted)
Boiling Point :
~641.1° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Inositol phosphate formation evoked by 5-HT: IC50 = 7.76 nM
Ki Data :
SR-2A: Ki= 0.26 nM; D4DR: Ki= 2.93 nM; Histamine H1 Receptor: Ki= 25 nM; α1 receptor: Ki= 38 nM; SR-1A: Ki= 70 nM; D2DR: Ki= 726 nM
pK Values :
pKb: 7.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60785
MDL Number :
MFCD00866648
SMILES :
C1CN(CCN1CCCN2C3=CC=CC4=C3C(=CC=C4)S2(=O)=O)C5=CC=C(C=C5)F

Download SDS (MSDS)

Certificate of Analysis

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