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Fananserin is a potent 5-HT2A and D4 receptor (dopamine D4) antagonist, with efficacy against histamine H1, α1 and 5HT having Ki values of 0.26, 2.93, 25, 38, 70, and 726 nM, respectively. Fananserin shows very modest efficacy towards Dopamine D2 receptors with a Ki value of 726 nM.
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