FAM49B Antibody (D-8): sc-390478

FAM49B Antibody (D-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects FAM49B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FAM49B Antibody (D-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FAM49B, also known as family with sequence similarity 49, member B, is a 324 amino acid protein that plays a crucial role in cellular processes, including apoptosis and cell proliferation, making FAM49B significant in understanding various diseases, including endometriosis and certain cancers. FAM49B exists in two alternatively spliced isoforms, which may exhibit different functional properties and regulatory mechanisms. FAM49B is encoded by a gene located on human chromosome 8q24.21, a region implicated in several genetic disorders and cancers. Notably, alterations in chromosome 8, such as translocations and amplifications of the c-Myc gene, are often associated with poor prognoses in leukemias and lymphomas. Additionally, chromosome 8 has been linked to psychiatric conditions like schizophrenia and bipolar disorder, highlighting FAM49B′s importance in both cancer and mental health research.

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FAM49B Antibody (D-8) References:

1. Chromosomes 8 and 10 workshop.  |  Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
2. Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced.  |  Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
3. Cytogenetic mapping of a novel locus for type II Waardenburg syndrome.  |  Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
4. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
5. DNA sequence and analysis of human chromosome 8.  |  Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
6. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.  |  Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
7. Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis.  |  Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002
8. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.  |  Williams, KE., et al. 2015. J Proteomics. 113: 194-205. PMID: 25284053

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FAM49B Antibody (D-8) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FAM49B Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FAM49B Antibody (D-8) Specifications

Alternate Product Name: FAM49B

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 8-20

Epitope Target: FAM49B

Epitope Species: human

Product Reactivity/Detection: FAM49B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FAM49B Antibody (D-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin