FAM120A Antibody (1501CT803.19.85.5): sc-517328

FAM120A Antibody (1501CT803.19.85.5) is a mouse monoclonal IgG1 kappa light chain antibody that detects FAM120A protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-FAM120A antibody (1501CT803.19.85.5) is available as a non-conjugated format. FAM120A, also known as OSSA (Oxidative stress-associated Src activator) or C9orf10, is a 1,118 amino acid tumor suppressor that plays a critical role in cellular signaling pathways, particularly in response to oxidative stress. FAM120A is primarily located in the cytoplasm and cell membrane, which is significant because this localization is essential for activating Src family kinases, thereby influencing cell survival and proliferation under stress conditions. FAM120A is ubiquitously expressed, with notably high levels found in scirrhous-type gastric cancer tissues compared to normal gastric mucosa, highlighting its potential role in cancer biology. As a member of the constitutive coactivator of PPAR-gamma family, FAM120A not only binds RNA but also promotes the secretion of insulin-like growth factor II (IGF-II) and exists in five alternatively spliced isoforms, which may contribute to its diverse functional roles. The gene encoding FAM120A is located on human chromosome 9, which encompasses approximately 145 million bases and accounts for about 4% of the human genome, encoding nearly 900 genes, thus underscoring the complexity and importance of this protein in various biological processes.

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FAM120A Antibody (1501CT803.19.85.5) References:

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