FAM109B Antibody (F-7): sc-390442
- FAM109B Antibody (F-7) is a mouse monoclonal mouse IgG2a κ κ provided at 200 µg/ml
- raised against amino acids 66-120 mapping within an internal region of FAM109B of human origin
- recommended for detection of FAM109B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for FAM109B Antibody (F-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with FAM109B Antibody (F-7) (see ordering information below).
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FAM109B Antibody (F-7) is a mouse monoclonal IgG2a antibody that detects FAM109B in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FAM109B, also known as IPIP27B, Sesquipedalian-2, or Ses2, is a 259 amino acid protein that plays a crucial role in cellular processes by localizing to early and recycling endosomes, the trans-Golgi network, and macropinosomes, which are essential for intracellular trafficking and signaling. FAM109B presence in these compartments is vital for maintaining cellular homeostasis and facilitating membrane protein recycling, thereby influencing various signaling pathways. FAM109B forms homodimers and heterodimers with FAM109A, and both proteins interact with the C-terminal region of inositol polyphosphate 5-phosphatases OCRL1 and Inpp5b. Disruptions in these interactions are implicated in the pathology of Lowe syndrome and type 2 Dent disease, conditions characterized by significant ocular, renal, and neurological defects. Anti-FAM109B antibody (F-7) is an invaluable tool for researchers studying these diseases and the underlying mechanisms of endosomal trafficking.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAM109B Antibody (F-7) | sc-390442 | 200 µg/ml | $322.00 | |||
FAM109B Antibody (F-7): m-IgG2a BP-HRP Bundle | sc-546073 | 200 µg Ab; 10 µg BP | $361.00 |