FADS1 Antibody (7-RY13): sc-134337

FADS1 Antibody (7-RY13) is a mouse monoclonal IgG2a kappa light chain antibody that detects the FADS1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FADS1 antibody (7-RY13) is available as the non-conjugated format. FADS1, also known as Delta(5) desaturase or D5D, is a crucial enzyme in the fatty acid desaturation process, playing a significant role in lipid metabolism by converting linoleic acid and alpha-linolenic acid into highly unsaturated fatty acids. This 444 amino acid protein is predominantly expressed in the liver, brain, adrenal gland, and heart, and is localized to the endoplasmic reticulum, where FADS1 functions as a multi-pass membrane protein. FADS1′s importance lies not only in enzymatic activity but also in structural features, which include N-terminal cytochrome b5-like domains and C-terminal multiple membrane-spanning regions that are essential for function. These structural characteristics enable FADS1 to effectively catalyze the desaturation of dihomo-gamma-linoleic acid and eicosatetraenoic acid, leading to the production of arachidonic acid and eicosapentaenoic acid, respectively. Furthermore, variations in the FADS gene cluster, including single nucleotide polymorphisms, have been implicated in various inflammatory and immune-related diseases, highlighting FADS1′s relevance in health and disease.

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FADS1 Antibody (7-RY13) References:

1. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase.  |  Cho, HP., et al. 1999. J Biol Chem. 274: 37335-9. PMID: 10601301
2. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.  |  Marquardt, A., et al. 2000. Genomics. 66: 175-83. PMID: 10860662
3. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids.  |  Schaeffer, L., et al. 2006. Hum Mol Genet. 15: 1745-56. PMID: 16670158
4. A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase.  |  Dreesen, TD., et al. 2006. Prostaglandins Leukot Essent Fatty Acids. 75: 97-106. PMID: 16846730
5. Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.  |  Risé, P., et al. 2007. Eur J Pharmacol. 571: 97-105. PMID: 17655842
6. SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.  |  Malerba, G., et al. 2008. Lipids. 43: 289-99. PMID: 18320251

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FADS1 Antibody (7-RY13) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FADS1 Antibody (7-RY13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FADS1 Antibody (7-RY13) Specifications

Alternate Product Name: FADS1

Product Clone Name: 7-RY13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-100

Epitope Target: FADS1

Epitope Species: human

Product Reactivity/Detection: FADS1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FADS1 Antibody (7-RY13): N/A