Fadrozole hydrochloride CAS: 102676-31-3
MF: C14H13N3•HCl
MW: 259.73
A very potent and selective inhibitory effect of the aromatase enzyme system.

Fadrozole hydrochloride  (CAS 102676-31-3)

Fadrozole hydrochloride, CAS 102676-31-3 is rated 5.0 out of 5 by 1.
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Synonym: Afema; 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile
Application: A very potent and selective inhibitory effect of the aromatase enzyme system
CAS Number: 102676-31-3
Molecular Weight: 259.73
Molecular Formula: C14H13N3•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fadrozole hydrochloride is a nonsteroidal aromatase inhibitor exhibiting a very potent and selective inhibitory effect of the aromatase enzyme system in vitro and estrogen biosynthesis in vivo. Fadrozole hydrochloride has been studied as a potential breast cancer regressor due to its ability to reduce estrogen synthesis.


References

Van Meeuwen, J., et al., Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study. Toxicol. Appl. Pharmacol. 228, 269-276, (2008) Minnaard-Huiban, M., et al., Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology 149, 28-31, (2008) Mikolajczyk, T., et al., The effect of aromatase inhibitor, fadrozole, on sGnRHa stimulated LH secretion in goldfish (Carassius auratus) and common carp (Cyprinus carpio). Reprod. Biol. 6, 195-199, (2006)

Physical State :
Solid
Solubility :
Soluble in DMSO: >20 mg/mL
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
59694
MDL Number :
MFCD00866239
SMILES :
C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N.Cl

Download SDS (MSDS)

Certificate of Analysis

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can I get Fadrozole hydrochloride in japan and if yes how and what is the price in japanese yen

Asked by: abdalla
Thank you for your question. For accurate availability and shipping information regarding of our chemical products, including Fadrozole Hydrochloride, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: [email protected] or by live chat directly on our website, www.scbt.com. Alternatively you can contact one of our authorized distributors in Japan, you can find their contact information here: https://www.scbt.com/scbt/resources/distributors
Answered by: Tech Service
Date published: 2016-10-28
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Rated 5 out of 5 by from Luzio A; et al Luzio A; et al. (PubMed ID: 26240953) determined that increased the masculinization in the sexual development in zebrafish. -SCBT Publication Review
Date published: 2015-04-10
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