Molecular structure of Fadrozole hydrochloride, CAS Number: 102676-31-3
Fadrozole hydrochloride (CAS 102676-31-3)
Alternate Names:
Afema; 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile
Application:
Fadrozole hydrochloride is a very potent and selective inhibitory effect of the aromatase enzyme system
CAS Number:
102676-31-3
Molecular Weight:
259.73
Molecular Formula:
C14H13N3•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Fadrozole hydrochloride is an organic compound known for its role in biochemical research. This chemical belongs to the class of compounds known as aromatase inhibitors, which are characterized by their ability to interfere with the enzyme aromatase. Chemically, fadrozole hydrochloride is the hydrochloride salt form of fadrozole. It typically appears as a white or off-white crystalline powder that is soluble in water, making it suitable for use in various aqueous solutions for research purposes. The addition of the hydrochloride group to fadrozole enhances its solubility and stability, facilitating its handling and application in laboratory applications.
Fadrozole hydrochloride (CAS 102676-31-3) References
- Delayed implantation induced by fadrozole hydrochloride in rats. | Tamada, H., et al. 2003. Contraception. 68: 65-8. PMID: 12878290
- The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats. | Tamada, H., et al. 2004. J Endocrinol. 180: 337-45. PMID: 14765986
- Specificity of low dose fadrozole hydrochloride (CGS 16949A) as an aromatase inhibitor. | Santen, RJ., et al. 1991. J Clin Endocrinol Metab. 73: 99-106. PMID: 1646219
- Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. | Browne, LJ., et al. 1991. J Med Chem. 34: 725-36. PMID: 1825337
- Metabolomic, behavioral, and reproductive effects of the aromatase inhibitor fadrozole hydrochloride on the unionid mussel Lampsilis fasciola. | Leonard, JA., et al. 2014. Gen Comp Endocrinol. 206: 213-26. PMID: 25072892
- Synergistic effect of fadrozole and insulin-like growth factor-I on female-to-male sex reversal and body weight of broiler chicks. | Mohammadrezaei, M., et al. 2014. PLoS One. 9: e103570. PMID: 25075864
- Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. | Gunson, DE., et al. 1995. Br J Cancer. 72: 72-5. PMID: 7639848
- Fadrozole: a potent and specific inhibitor of aromatase in the zebra finch brain. | Wade, J., et al. 1994. Gen Comp Endocrinol. 94: 53-61. PMID: 8045368
- Structure-activity relationships and binding model of novel aromatase inhibitors. | Lang, M., et al. 1993. J Steroid Biochem Mol Biol. 44: 421-8. PMID: 8476755
- Studies on the effect of the new non-steroidal aromatase inhibitor fadrozole hydrochloride in an endometriosis model in rats. | Yano, S., et al. 1996. Arzneimittelforschung. 46: 192-5. PMID: 8720312
- Recovery of reproductive function in rats treated with the aromatase inhibitor fadrozole. | Nunez, SB., et al. 1996. Reprod Toxicol. 10: 373-7. PMID: 8888409
- Aromatase inhibitors as potential cancer chemopreventives. | Kelloff, GJ., et al. 1998. Cancer Epidemiol Biomarkers Prev. 7: 65-78. PMID: 9456245
- Effect of the potent aromatase inhibitor fadrozole hydrochloride (CGS 16949A) in postmenopausal women with breast carcinoma. | Costa, LA., et al. 1999. Cancer. 85: 100-3. PMID: 9921980
Inhibitor of:
11β-HSD2, 17β-HSD3, BBOX1, CYP11B, CYP19, Estrogen Related Receptor, and LOC100039517.Activator of:
17β-HSD, 17β-HSD14, 3β-HSD3, and Etd.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fadrozole hydrochloride, 10 mg | sc-252819 | 10 mg | $138.00 | |||
Fadrozole hydrochloride, 50 mg | sc-252819A | 50 mg | $530.00 | |||
Fadrozole hydrochloride, 500 mg | sc-252819B | 500 mg | $4080.00 |