Factor XII heavy chain Antibody (B7C9): sc-59518

Factor XII heavy chain Antibody (B7C9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Factor XII heavy chain protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Factor XII heavy chain antibody (B7C9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Factor XII heavy chain (B7C9) antibody recognizes a protein that plays a crucial role in the blood coagulation cascade, initiating the process of hemostasis following tissue injury. Factor XII heavy chain (B7C9) monoclonal antibody targets a serine protease that activates Factor XI and prekallikrein, leading to the formation of fibrin clots and promoting platelet aggregation. The importance of Factor XII extends beyond coagulation, as Factor XII is also involved in the generation of bradykinin and angiotensin, which are vital for regulating blood pressure and inflammatory responses. Notably, the heavy chain of human Factor XII has a dissociation constant of 9.8 nM, indicating its strong binding affinity, which is essential for its function in the coagulation pathway. Factor XII deficiency, while rare, can increase the risk of thromboembolic events, highlighting Factor XII′s significance in maintaining vascular health. The gene encoding human Factor XII is located on the long arm of chromosome 5 (5q33-qter), underscoring its genetic relevance in studies of coagulation disorders.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Factor XII heavy chain Antibody (B7C9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Factor XII heavy chain Antibody (B7C9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Factor XII heavy chain Antibody (B7C9) Specifications

Alternate Product Name: Factor XII heavy chain

Product Clone Name: B7C9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Factor XII heavy chain

Epitope Species: human

Product Reactivity/Detection: Factor XII heavy chain

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Factor XII heavy chain Antibody (B7C9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Factor XII antibody is Factor XII Antibody (C-8): sc-376770.