Factor X Antibody (AMX-9050): sc-73462
- Factor X Antibody (AMX-9050) is a rat monoclonal IgG, cited in 1 publications, provided at 100 µg/ml
- raised against Factor X of mouse origin
- recommended for detection of Factor X and Factor X A of mouse origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Factor X Antibody (AMX-9050). This work is in progress.
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Factor X Antibody (AMX-9050) is a rat monoclonal IgG antibody that detects Coagulation Factor X in mouse samples by western blotting (WB). Factor X, also known as Stuart Prower factor, plays a crucial role in the hemostatic process following tissue injury, as Coagulation Factor X is a key component of the blood coagulation cascade that leads to the formation of fibrin clots and platelet aggregation. This vitamin K-dependent serine protease is synthesized in the liver and circulates as an inactive precursor until activated through cleavage by either Factor IX A or Factor VII A, resulting in the formation of active Factor X A. Factor X A forms a complex with Factor V A and calcium ions on the surface of platelets or endothelial cells, which is essential for converting prothrombin to thrombin, a critical step in the coagulation process. Deficiencies in Factor X due to mutations at the Factor X locus can lead to serious bleeding disorders, highlighting the significance of Factor X in maintaining hemostatic balance. Anti-Factor X antibody (AMX-9050) serves as an invaluable tool for researchers studying coagulation pathways and related disorders, providing insights into the mechanisms of hemostasis and potential therapeutic targets.
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Factor X Antibody (AMX-9050) References:
- The site of activation of factor X by cancer procoagulant. | Gordon, SG. and Mourad, AM. 1991. Blood Coagul Fibrinolysis. 2: 735-9. PMID: 1799660
- Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X. | Kamocka, M., et al. 2008. Comp Med. 58: 282-6. PMID: 18589871
- ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. | Cubillos-Ruiz, JR., et al. 2015. Cell. 161: 1527-38. PMID: 26073941
- Co-localization of Coagulation Factor X and its Inhibitory System, PZ/ZPI, in Human Endometrial Cancer Tissue. | Sierko, E., et al. 2019. In Vivo. 33: 771-776. PMID: 31028196
- MYC as a target for cancer treatment. | Duffy, MJ., et al. 2021. Cancer Treat Rev. 94: 102154. PMID: 33524794
- Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. | Nanjo, S., et al. 2022. J Clin Invest. 132: PMID: 35579943
- miR-22 Suppresses EMT by Mediating Metabolic Reprogramming in Colorectal Cancer through Targeting MYC-Associated Factor X. | Xia, S., et al. 2022. Dis Markers. 2022: 7843565. PMID: 36061355
- Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients? | Poenou, G., et al. 2023. Int J Mol Sci. 24: PMID: 37833881
- Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer. | Calì, B., et al. 2024. Cancer Cell. 42: 1676-1692.e11. PMID: 39303726
- Cancer procoagulant: a factor X activator, tumor marker and growth factor from malignant tissue. | Gordon, SG. and Mielicki, WP. 1997. Blood Coagul Fibrinolysis. 8: 73-86. PMID: 9518049
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor X Antibody (AMX-9050) | sc-73462 | 100 µg/ml | $316.00 |