Factor I Antibody (KT22): sc-101481

Factor I Antibody (KT22) is a mouse monoclonal IgG2b antibody that detects the complement Factor I protein of human origin by enzyme-linked immunosorbent assay (ELISA). Factor I plays a crucial role in the regulation of the complement system, which is essential for both innate and adaptive immunity. This serine protease modulates the complement cascade by cleaving C3b and C4b, thereby preventing excessive inflammation and tissue damage. Factor I primarily circulates in the plasma as a heavily N-glycosylated heterodimer composed of two disulfide-linked chains, each adorned with three N-linked oligosaccharide chains. These glycosylations are vital for Factor I′s interactions with natural substrates and cofactors during catalysis. Factor I requires protein cofactors such as Factor H, CR1, or MCP for the cleavage of C3b, and C4bp or CR1 for the cleavage of C4b, highlighting the importance of these interactions in maintaining immune homeostasis. Factor I (KT22) antibody serves as an invaluable tool for researchers studying the complement system and its implications in various diseases, making Factor I (KT22) monoclonal antibody a significant addition to any laboratory focused on immunology and related fields.