Molecular structure of Exotoxin A, Pseudomonas aeruginosa, CAS Number: 91262-95-2
Exotoxin A, Pseudomonas aeruginosa (CAS 91262-95-2)
Application:
Exotoxin A, Pseudomonas aeruginosa is protein synthesis inhibitor via Bak expression level regulation
CAS Number:
91262-95-2
Molecular Weight:
66000
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This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Exotoxin A, a bacterial toxin originally derived from Pseudomonas aeruginosa, has been shown to arrest protein synthesis and cause apoptosis. Mechanistic studies suggest that this compound causes apoptosis via Bak regulation. Additional experiments report that exposure of cells to Exotoxin A results in an increase in TNF-α, IL-2, IL-6, and IL-10 levels which eventually lead to apoptosis.
Exotoxin A, Pseudomonas aeruginosa (CAS 91262-95-2) References
- Pseudomonas exotoxin A: from virulence factor to anti-cancer agent. | Wolf, P. and Elsässer-Beile, U. 2009. Int J Med Microbiol. 299: 161-76. PMID: 18948059
- Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity: an animal model in rats. | Chiu, CC., et al. 2009. J Vet Med Sci. 71: 1-8. PMID: 19194069
- Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. | Du, X., et al. 2010. Mol Cell Biol. 30: 3444-52. PMID: 20457813
- Analysis of the structure-function relationship of Pseudomonas aeruginosa exotoxin A. | Wick, MJ., et al. 1990. Mol Microbiol. 4: 527-35. PMID: 2112672
- Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A. | Wick, MJ., et al. 1990. Annu Rev Microbiol. 44: 335-63. PMID: 2123620
- Host-pathogen interactions: The role of Pseudomonas aeruginosa exotoxin A in modulation of Galleria mellonella immune response. | Iwański, B. and Andrejko, M. 2022. J Invertebr Pathol. 187: 107706. PMID: 34919944
- Pseudomonas aeruginosa exotoxin A induces apoptosis in Galleria mellonella hemocytes. | Iwański, B., et al. 2023. J Invertebr Pathol. 197: 107884. PMID: 36642365
- Structural Insights into Pseudomonas aeruginosa Exotoxin A-Elongation Factor 2 Interactions: A Molecular Dynamics Study. | Gholami, A., et al. 2023. J Chem Inf Model. 63: 1578-1591. PMID: 36802593
- New insights on Pseudomonas aeruginosa exotoxin A-based immunotoxins in targeted cancer therapeutic delivery. | Morgan, RN., et al. 2023. Ther Deliv. 14: 31-60. PMID: 36950853
- In silico Validation of Pseudomonas aeruginosa Exotoxin A Domain I Interaction with the Novel Human scFv Antibody. | Shadman, Z., et al. 2023. Infect Disord Drug Targets. 23: e290323215113. PMID: 36999425
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Sec61α1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exotoxin A, Pseudomonas aeruginosa, 0.5 mg | sc-203949 | 0.5 mg | $587.00 |