Evx-1 Antibody (397.3): sc-81962

Evx-1 Antibody (397.3) is a mouse monoclonal IgG2a kappa light chain antibody that detects Evx-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Evx-1 antibody (397.3) is available as a non-conjugated format. Evx-1 protein plays a critical role in embryonic development, particularly in the hindbrain, genital bud, developing neural tube, and distal limb, where Evx-1 is essential for proper tissue differentiation and organogenesis. Evx-1 is a member of the homeodomain transcription factor family, which regulates gene expression to orchestrate developmental processes across eukaryotic species. Notably, Evx-1 is closely linked to the Hox gene cluster on mouse chromosome 6, and Evx-1 expression is influenced by growth factors such as FGF-4, highlighting Evx-1′s importance in signaling pathways that govern developmental timing and spatial organization. The interaction between Evx-1 and Hox genes is particularly significant, as this interaction underscores the intricate regulatory networks that guide embryonic patterning and the establishment of regional identities along the body axes. Using anti-Evx-1 antibody (397.3) in research can provide valuable insights into the molecular mechanisms underlying development and the potential implications for understanding congenital disorders.

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Evx-1 Antibody (397.3) References:

1. Amphioxus Evx genes: implications for the evolution of the Midbrain-Hindbrain Boundary and the chordate tailbud.  |  Ferrier, DE., et al. 2001. Dev Biol. 237: 270-81. PMID: 11543613
2. Genesis and evolution of the Evx and Mox genes and the extended Hox and ParaHox gene clusters.  |  Minguillón, C. and Garcia-Fernàndez, J. 2003. Genome Biol. 4: R12. PMID: 12620122
3. Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak.  |  Dush, MK. and Martin, GR. 1992. Dev Biol. 151: 273-87. PMID: 1349539
4. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication.  |  Lehoczky, JA., et al. 2004. Evol Dev. 6: 423-30. PMID: 15509224
5. HOXA gene cluster rearrangement in a t(7;9)(p15;q34) in a child with MDS.  |  Poppe, B., et al. 2005. Cancer Genet Cytogenet. 162: 82-4. PMID: 16157206
6. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord.  |  Yang, X., et al. 2006. Dev Neurosci. 28: 102-17. PMID: 16508308
7. FGF-4 regulates expression of Evx-1 in the developing mouse limb.  |  Niswander, L. and Martin, GR. 1993. Development. 119: 287-94. PMID: 7506139
8. Function of FGF-4 in limb development.  |  Niswander, L., et al. 1994. Mol Reprod Dev. 39: 83-8; discussion 88-9. PMID: 7999365
9. Function of the Evx-2 gene in the morphogenesis of vertebrate limbs.  |  Hérault, Y., et al. 1996. EMBO J. 15: 6727-38. PMID: 8978698

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Evx-1 Antibody (397.3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Evx-1 Antibody (397.3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Evx-1 Antibody (397.3) Specifications

Alternate Product Name: Evx-1

Product Clone Name: 397.3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 2-110

Epitope Target: Evx-1

Epitope Species: human

Product Reactivity/Detection: Evx-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Evx-1 Antibody (397.3): N/A