Date published: 2025-10-19

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Evodiamine (CAS 518-17-2)

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Application:
Evodiamine is an antiangiogenic and antiinflammatory agonist of TRPV1
CAS Number:
518-17-2
Purity:
97%
Molecular Weight:
303.4
Molecular Formula:
C19H17N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Evodiamine is a chemical compound that is of particular interest in the field of natural products research. It is often utilized in studies examining thermogenic and metabolism properties due to its potential to influence energy expenditure. In biochemical research, evodiamine is used to investigate its effects on various signaling pathways, including those that regulate fat metabolism and the mobilization of lipids. Furthermore, researchers employ evodiamine in the study of its interaction with transient receptor potential vanilloid receptors, which are involved in the perception of heat and the modulation of temperature in organisms. These research applications contribute to a broader understanding of cellular metabolism and energy regulation.


Evodiamine (CAS 518-17-2) References

  1. Evodiamine functions as an agonist for the vanilloid receptor TRPV1.  |  Pearce, LV., et al. 2004. Org Biomol Chem. 2: 2281-6. PMID: 15305207
  2. Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity.  |  Shyu, KG., et al. 2006. Life Sci. 78: 2234-43. PMID: 16280136
  3. Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms.  |  Choi, YH., et al. 2006. Arch Pharm Res. 29: 293-7. PMID: 16681034
  4. Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells.  |  Lee, TJ., et al. 2006. Mol Cancer Ther. 5: 2398-407. PMID: 16985074
  5. Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis.  |  Jiang, ZB., et al. 2020. J Exp Clin Cancer Res. 39: 249. PMID: 33208183
  6. Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway.  |  Ye, C., et al. 2021. Phytother Res. 35: 3406-3417. PMID: 33657655
  7. Retracted: Evodiamine Induces Apoptosis, G2/M Cell Cycle Arrest, and Inhibition of Cell Migration and Invasion in Human Osteosarcoma Cells via Raf/MEK/ERK Signalling Pathway.  |  Zhou, Y. and Hu, J. 2021. Med Sci Monit. 27: e932330. PMID: 33762570
  8. Evodiamine Inhibits Helicobacter pylori Growth and Helicobacter pylori-Induced Inflammation.  |  Yang, JY., et al. 2021. Int J Mol Sci. 22: PMID: 33806161
  9. Evodiamine Relieve LPS-Induced Mastitis by Inhibiting AKT/NF-κB p65 and MAPK Signaling Pathways.  |  Yang, Y., et al. 2022. Inflammation. 45: 129-142. PMID: 34401976
  10. Evodiamine induces ROS-Dependent cytotoxicity in human gastric cancer cells via TRPV1/Ca2+ pathway.  |  Liu, L., et al. 2022. Chem Biol Interact. 351: 109756. PMID: 34808100
  11. [Cytotoxicity and underlying mechanism of evodiamine in HepG2 cells].  |  Gao, YD., et al. 2021. Beijing Da Xue Xue Bao Yi Xue Ban. 53: 1107-1114. PMID: 34916690
  12. Amelioration of AOM/DSS-Induced Murine Colitis-Associated Cancer by Evodiamine Intervention is Primarily Associated with Gut Microbiota-Metabolism-Inflammatory Signaling Axis.  |  Wang, M., et al. 2021. Front Pharmacol. 12: 797605. PMID: 35002731
  13. Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages.  |  Chiou, WF., et al. 1997. J Nat Prod. 60: 708-11. PMID: 9249975

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Evodiamine, 20 mg

sc-201479
20 mg
$20.00

Evodiamine, 100 mg

sc-201479A
100 mg
$71.00