Evernic acid (CAS 537-09-7)
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Evernic acid is a secondary metabolite produced by some species of lichen. Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of FAS-II enzymes. Potential toxicity of Evernic acid was assessed in human hepatocyte and cancer cells as well as in a zebrafish model. This study indicates there could be therapeutic and prophylactic potential of Evernic acid as an antibacterial and antiplasmodial agent. Evernic acid has also been evaluated for clastogenic and antiproliferative effects on human lymphocytes, however the investigation showed Evernic acid did not show a statistically significant inhibitory effect on lymphocyte cell proliferation at the applied concentrations.
Evernic acid (CAS 537-09-7) References
- Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target. | Lauinger, IL., et al. 2013. J Nat Prod. 76: 1064-70. PMID: 23806111
- Clastogenic effect of atranorin, evernic acid, and usnic acid on human lymphocytes. | Stojanović, GS., et al. 2014. Nat Prod Commun. 9: 503-4. PMID: 24868868
- Protective effects of lichen metabolites evernic and usnic acids against redox impairment-mediated cytotoxicity in central nervous system-like cells. | Fernández-Moriano, C., et al. 2017. Food Chem Toxicol. 105: 262-277. PMID: 28450128
- Simultaneous determination of usnic, diffractaic, evernic and barbatic acids in rat plasma by ultra-high-performance liquid chromatography-quadrupole exactive Orbitrap mass spectrometry and its application to pharmacokinetic studies. | Wang, H., et al. 2018. Biomed Chromatogr. 32: PMID: 29055065
- DFT and QTAIM based investigation on the structure and antioxidant behavior of lichen substances Atranorin, Evernic acid and Diffractaic acid. | Shameera Ahamed, TK., et al. 2019. Comput Biol Chem. 80: 66-78. PMID: 30928870
- Lichens in Genus Parmelia: An Overview and their Application. | Gandhi, AD., et al. 2020. Curr Pharm Biotechnol. 21: 1289-1297. PMID: 32250223
- Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson's Disease Model. | Lee, S., et al. 2021. Int J Mol Sci. 22: PMID: 33672606
- Lecanoric acid mediates anti-proliferative effects by an M phase arrest in colon cancer cells. | Roser, LA., et al. 2022. Biomed Pharmacother. 148: 112734. PMID: 35190352
- Effect of evernic acid on human breast cancer MCF-7 and MDA-MB-453 cell lines via thioredoxin reductase 1: A molecular approach. | Kalın, ŞN., et al. 2023. J Appl Toxicol. 43: 1148-1158. PMID: 36807289
- Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies. | Studzińska-Sroka, E., et al. 2023. Molecules. 29: PMID: 38202817
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Evernic acid, 100 mg | sc-294581 | 100 mg | $270.00 | |||
Evernic acid, 200 mg | sc-294581A | 200 mg | $536.00 | |||
Evernic acid, 500 mg | sc-294581B | 500 mg | $1326.00 |