EVC2 Antibody (F-12): sc-393128

EVC2 Antibody (F-12) is a mouse monoclonal IgM antibody that detects EVC2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-EVC2 antibody (F-12) is available as the non-conjugated form. EVC2, also known as limbin, plays a crucial role in the development of various tissues, particularly in the formation of vertebral bodies, kidneys, ribs, lungs, and limbs, as well as the heart. EVC2 function is essential for normal skeletal development and organ formation, and mutations in EVC2 can lead to significant developmental disorders. Specifically, EVC2 is implicated in Ellis-van Creveld syndrome (EVC) and Weyers acrodental dysostosis (WAD), both characterized by skeletal abnormalities and other systemic issues. EVC is an autosomal recessive disorder that often results in severe heart defects, while WAD, an autosomal dominant condition, presents with milder symptoms but still includes short stature and dysplastic nails. EVC2′s ability to interact with other proteins involved in cellular signaling pathways further underscores its importance in developmental biology and disease pathology, making anti-EVC2 antibody (F-12) a valuable tool for researchers studying these conditions.

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EVC2 Antibody (F-12) References:

1. Ellis-van Creveld syndrome and the Amish.  |  McKusick, VA. 2000. Nat Genet. 24: 203-4. PMID: 10700162
2. Ellis-van Creveld syndrome resulting from segmental uniparental disomy of chromosome 4.  |  Tompson, SW., et al. 2001. J Med Genet. 38: E18. PMID: 11389165
3. Ellis-van Creveld Syndrome: a report of two cases.  |  Arya, L., et al. 2001. Pediatr Dermatol. 18: 485-9. PMID: 11841633
4. Images in cardiology: Common atrium in a child with Ellis-Van Creveld syndrome.  |  Sajeev, CG., et al. 2002. Heart. 88: 142. PMID: 12117837
5. A new gene, EVC2, is mutated in Ellis-van Creveld syndrome.  |  Galdzicka, M., et al. 2002. Mol Genet Metab. 77: 291-5. PMID: 12468274
6. Mutations in two nonhomologous genes in a head-to-head configuration cause Ellis-van Creveld syndrome.  |  Ruiz-Perez, VL., et al. 2003. Am J Hum Genet. 72: 728-32. PMID: 12571802
7. Ellis-van creveld syndrome, Jeune syndrome, and renal-hepatic-pancreatic dysplasia: separate entities or disease spectrum?  |  Brueton, LA., et al. 1990. J Med Genet. 27: 252-5. PMID: 2325105
8. Exclusion of the MSX1 homeobox gene as the gene for the Ellis van Creveld syndrome in the Amish.  |  Ide, SE., et al. 1996. Hum Genet. 98: 572-5. PMID: 8882877

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EVC2 Antibody (F-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-EVC2 Antibody (F-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EVC2 Antibody (F-12) Specifications

Alternate Product Name: EVC2

Product Clone Name: F-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 57-89

Epitope Target: EVC2

Epitope Species: mouse

Product Reactivity/Detection: EVC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for EVC2 Antibody (F-12): P: Blocking Peptide