Eurycomanone (CAS 84633-29-4)
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Eurycomanone is a quassinoid compound that has become a focal point in research due to its presence in Eurycoma longifolia, known as Tongkat Ali or Malaysian ginseng. In plant biology, eurycomanone is studied for its role in the plant′s defense mechanisms against herbivores and pathogens. It is of particular interest in the field of natural product chemistry for its diverse bioactivities, prompting studies on its mechanism of action at the molecular level. Researchers are also keen on exploring its potential as a lead compound for the development of new bioactive substances. Additionally, eurycomanone is employed in analytical studies aimed at the standardization and quality control of herbal supplements containing Eurycoma longifolia extracts. Studies in environmental science may investigate how eurycomanone and its derivatives are metabolized and degraded in various ecosystems.
Eurycomanone (CAS 84633-29-4) References
- Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53. | Zakaria, Y., et al. 2009. Cancer Cell Int. 9: 16. PMID: 19508737
- Comparative X-ray and conformational analysis of a new crystal of 13α,21-dihydroeurycomanone with eurycomanone from Eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay. | Teh, CH., et al. 2011. Planta Med. 77: 128-32. PMID: 20665368
- Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. | Wong, PF., et al. 2012. Phytomedicine. 19: 138-44. PMID: 21903368
- Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. | Low, BS., et al. 2013. J Ethnopharmacol. 149: 201-7. PMID: 23810842
- Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro. | Pan, Y., et al. 2014. J Nat Med. 68: 402-6. PMID: 23881640
- Eurycomanone and eurycomanol from Eurycoma longifolia Jack as regulators of signaling pathways involved in proliferation, cell death and inflammation. | Hajjouli, S., et al. 2014. Molecules. 19: 14649-66. PMID: 25230121
- Determination of eurycomanone in rat plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry for pharmacokinetic study. | Rehman, SU., et al. 2017. Biomed Chromatogr. 31: PMID: 27572280
- Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia. | Lahrita, L., et al. 2017. Bioorg Med Chem. 25: 4829-4834. PMID: 28760530
- Production of eurycomanone from cell suspension culture of Eurycoma longifolia. | Nhan, NH. and Loc, NH. 2017. Pharm Biol. 55: 2234-2239. PMID: 29130786
- Development of a selective HPLC-DAD/ELSD method for the qualitative and quantitative assessment of commercially available Eurycoma longifolia products and plant extracts. | Mutschlechner, B., et al. 2018. Fitoterapia. 124: 188-192. PMID: 29154863
- Antiadipogenic effects of a standardized quassinoids-enriched fraction and eurycomanone from Eurycoma longifolia. | Balan, D., et al. 2018. Phytother Res. 32: 1332-1345. PMID: 29520860
- Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract. | Ahmad, N., et al. 2018. Pharmaceutics. 10: PMID: 29997335
- The botanical eurycomanone is a potent growth regulator of the diamondback moth. | Shao, X., et al. 2021. Ecotoxicol Environ Saf. 208: 111647. PMID: 33396167
- A Quassinoid Diterpenoid Eurycomanone from Eurycoma longifolia Jack Exerts Anti-Cancer Effect through Autophagy Inhibition. | Ye, G., et al. 2022. Molecules. 27: PMID: 35889271
- Eurycomanol and eurycomanone as potent inducers for cell-cycle arrest and apoptosis in small and large human lung cancer cell lines. | Okba, MM., et al. 2023. Nat Prod Res. 37: 1856-1862. PMID: 36054770
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eurycomanone, 1 mg | sc-497437 | 1 mg | $213.00 |