Molecular structure of EUK 134, CAS Number: 81065-76-1
EUK 134 (CAS 81065-76-1)
See product citations (5)
Alternate Names:
chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]]]-manganese
Application:
EUK 134 is a salen-manganese complex, superoxide dismutase mimetic
CAS Number:
81065-76-1
Molecular Weight:
416.74
Molecular Formula:
C18H18ClMnN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
EUK 134 is a synthetic manganese-porphyrin complex which has been documented to act as a scavenger for oxidative species such as hydrogen peroxide, peroxynitrite and superoxide. This compound is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity.
EUK 134 (CAS 81065-76-1) References
- EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. | Rong, Y., et al. 1999. Proc Natl Acad Sci U S A. 96: 9897-902. PMID: 10449791
- EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney. | Chatterjee, PK., et al. 2004. Am J Nephrol. 24: 165-77. PMID: 14752229
- A synthetic superoxide dismutase/catalase mimetic (EUK-134) inhibits membrane-damage-induced activation of mitogen-activated protein kinase pathways and reduces p53 accumulation in ultraviolet B-exposed primary human keratinocytes. | Decraene, D., et al. 2004. J Invest Dermatol. 122: 484-91. PMID: 15009734
- Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation. | Howard, MD., et al. 2014. J Control Release. 177: 34-41. PMID: 24412573
- EUK-134 ameliorates nNOSμ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading. | Lawler, JM., et al. 2014. Am J Physiol Regul Integr Comp Physiol. 306: R470-82. PMID: 24477538
- The manganese-salen compound EUK-134 and N-acetyl cysteine rescue from zinc- and paraquat-induced toxicity in rat polymorphonuclear leukocytes. | Kumar, A., et al. 2015. Chem Biol Interact. 231: 18-26. PMID: 25724285
- Preservation of renal blood flow by the antioxidant EUK-134 in LPS-treated pigs. | Magder, S., et al. 2015. Int J Mol Sci. 16: 6801-17. PMID: 25815596
- Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. | Purushothaman, S. and Nair, RR. 2016. Mol Cell Biochem. 420: 185-94. PMID: 27514538
- Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension. | Himori, K., et al. 2017. PLoS One. 12: e0169146. PMID: 28152009
- Effect of Eukarion-134 on Akt-mTOR signalling in the rat soleus during 7 days of mechanical unloading. | Kuczmarski, JM., et al. 2018. Exp Physiol. 103: 545-558. PMID: 29315934
- Treatment with EUK-134 improves sarcoplasmic reticulum Ca2+ release but not myofibrillar Ca2+ sensitivity after fatiguing contraction of rat fast-twitch muscle. | Watanabe, D., et al. 2019. Am J Physiol Regul Integr Comp Physiol. 316: R543-R551. PMID: 30794441
- Effects of electrotactic exercise and antioxidant EUK-134 on oxidative stress relief in Caenorhabditis elegans. | Pham, TTH., et al. 2021. PLoS One. 16: e0245474. PMID: 33471830
- Ab initio study of superoxide dismutase (SOD) and catalase activity of EUK-134. | Ri, MH., et al. 2022. J Mol Model. 28: 168. PMID: 35612680
- EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. | Gianello, P., et al. 1996. Transplantation. 62: 1664-6. PMID: 8970624
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EUK 134, 5 mg | sc-205321 | 5 mg | $50.00 | |||
EUK 134, 10 mg | sc-205321A | 10 mg | $96.00 |