Ets-1/Ets-2 Antibody (D-7): sc-374509

Ets-1/Ets-2 Antibody (D-7) is a mouse monoclonal IgM kappa light chain antibody engineered to detect both Ets-1 and Ets-2 proteins. Ets-1/Ets-2 (D-7) monoclonal antibody targets an epitope mapping to amino acids 353-383 within the conserved C-terminal domain of human Ets-1, enabling reliable detection in mouse, rat, human, canine, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ets-1 and Ets-2 are critical transcription factors within the ETS family, playing essential roles in regulating gene expression involved in cellular processes like proliferation, differentiation, apoptosis, and angiogenesis. The structural integrity of Ets-1 and Ets-2 includes a conserved ETS DNA-binding domain that facilitates interaction with specific DNA sequences, allowing control of target gene transcription and maintenance of cellular homeostasis. Post-translational modifications, particularly phosphorylation, are vital for modulating Ets-1 and Ets-2 activity, affecting protein interactions and influencing transcriptional activity. These transcription factors interact with various proteins, including co-activators such as p300 and other ETS family members like PU.1, FEV, Fli-1, and Erg-1/2/3, which are essential for precise regulation of gene expression and cellular responses. Dysregulation of Ets-1 and Ets-2 has been linked to numerous cancers and developmental disorders, underscoring their importance in both normal physiological functions and disease pathogenesis. Ets-1/Ets-2 (D-7) antibody provides researchers with a dependable tool to explore complex interactions and functional mechanisms of these transcription factors, facilitating advancements in understanding disease mechanisms and potential therapeutic targets.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ets-1/Ets-2 Antibody (D-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Ets-1/Ets-2 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ets-1/Ets-2 Antibody (D-7) Specifications

Alternate Product Name: ETS1/ETS2

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 353-383

Epitope Target: Ets-1

Epitope Species: human

Product Reactivity/Detection: Ets-1 and Ets-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Ets-1/Ets-2 Antibody (D-7): P: Blocking Peptide, X: TransCruz Reagent

The preferred Ets-1 antibody is Ets-1 Antibody (C-4): sc-55581.