Date published: 2025-12-18

1-800-457-3801

SCBT Portrait Logo
Seach Input

Etretinate (CAS 54350-48-0)

5.0(1)
Write a reviewAsk a question

Alternate Names:
Tegison
Application:
Etretinate is psoriasis medication shown to cause birth defects
CAS Number:
54350-48-0
Purity:
≥98%
Molecular Weight:
354.48
Molecular Formula:
C23H30O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Etretinate is a aromatic retinoid that functions as a potent modulator of cell growth and differentiation. It exerts its mechanism of action by binding to nuclear retinoic acid receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which are transcription factors that regulate gene expression. This binding leads to the activation or repression of target genes involved in cellular differentiation, proliferation, and apoptosis. Etretinate′s interaction with these receptors ultimately results in the modulation of various cellular processes, including the regulation of keratinocyte proliferation and differentiation. It may influence the expression of genes involved in lipid metabolism and immune response. Etretinate′s mechanism of action at the molecular level may be valuable for investigating the role of retinoids in cellular processes and gene regulation.


Etretinate (CAS 54350-48-0) References

  1. Pharmacokinetics and drug interactions of etretinate and acitretin.  |  Lambert, WE., et al. 1992. J Am Acad Dermatol. 27: S19-22. PMID: 1460119
  2. Combination-therapy cyclosporin-A--etretinate for psoriasis.  |  Korstanje, MJ. and van de Staak, WJ. 1990. Clin Exp Dermatol. 15: 172-3. PMID: 2364569
  3. The pharmacokinetics of etretinate and its metabolites in the dog.  |  Thongnopnua, P., et al. 1989. Drug Metab Dispos. 17: 473-80. PMID: 2573489
  4. Etretinate. Persistent serum levels after long-term therapy.  |  DiGiovanna, JJ., et al. 1989. Arch Dermatol. 125: 246-51. PMID: 2913962
  5. Pharmacokinetics of etretin and etretinate during long-term treatment of psoriasis patients.  |  Larsen, FG., et al. 1988. Pharmacol Toxicol. 62: 159-65. PMID: 2967472
  6. Pharmacokinetics of tazarotene and acitretin in psoriasis.  |  Heath, MS., et al. 2018. Expert Opin Drug Metab Toxicol. 14: 919-927. PMID: 30134735
  7. Acrokeratoelastoidosis treated with etretinate.  |  Handfield-Jones, S. and Kennedy, CT. 1987. J Am Acad Dermatol. 17: 881-2. PMID: 3680676
  8. Etretinate therapy in generalized pustular psoriasis (Zumbusch type). Immediate and long-term results.  |  Wolska, H., et al. 1985. Dermatologica. 171: 297-304. PMID: 3908171
  9. Etretinate therapy for psoriasis and other keratinizing disorders: a 10-year retrospective study in Singapore.  |  Shahidullah, M., et al. 1993. Int J Dermatol. 32: 686-9. PMID: 7691773
  10. Teratogenic risk with etretinate and acitretin treatment.  |  Geiger, JM., et al. 1994. Dermatology. 189: 109-16. PMID: 8075435
  11. Acitretin and etretinate. How and when they should be used.  |  Geiger, JM. and Saurat, JH. 1993. Dermatol Clin. 11: 117-29. PMID: 8435906
  12. Conversion of acitretin to etretinate in psoriatic patients is influenced by ethanol.  |  Larsen, FG., et al. 1993. J Invest Dermatol. 100: 623-7. PMID: 8491984
  13. [Trans-acitretin is metabolized back to etretinate. Importance for oral retinoid therapy].  |  Almond-Roesler, B. and Orfanos, CE. 1996. Hautarzt. 47: 173-7. PMID: 8647698

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Etretinate, 25 mg

sc-205689
25 mg
$92.00

Etretinate, 100 mg

sc-205689A
100 mg
$224.00