Date published: 2025-12-16

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Etonogestrel-d7 (Major)

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Alternate Names:
(17α)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one-d7; 3-Ketodesogestrel-d7; 3-Oxodesogestrel-d7
Application:
Etonogestrel-d7 (Major) is A biologically active labeled metabolite of Desogestrel.
Molecular Weight:
331.50
Molecular Formula:
C22H21D7O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Etonogestrel-d6 is a synthetic progestin that functions as a potent agonist at the progesterone receptor. It exerts its mechanism of action by binding to the progesterone receptor and modulating gene transcription, leading to the suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from the pituitary gland. This ultimately inhibits ovulation and alters the cervical mucus, making it less favorable for sperm penetration. Additionally, etonogestrel-d6 may also affect the endometrial lining, making it less suitable for implantation of a fertilized egg. At the molecular level, this compound interacts with the progesterone receptor, leading to conformational changes and the recruitment of co-regulatory proteins, ultimately influencing gene expression and downstream physiological effects. Overall, etonogestrel-d6 plays a specific functional role in modulating reproductive processes at the molecular and cellular level within experimental contexts.


Etonogestrel-d7 (Major) References

  1. Simultaneous online SPE-LC-MS/MS quantification of six widely used synthetic progestins in human plasma.  |  Moser, C., et al. 2012. Anal Bioanal Chem. 403: 961-72. PMID: 22160205
  2. Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study.  |  Nair, SG., et al. 2018. Biomed Chromatogr. 32: e4165. PMID: 29228469
  3. A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids.  |  Laszlo, CF., et al. 2019. J Pharm Biomed Anal. 175: 112756. PMID: 31387028
  4. Development and validation of a multiplexed assay for the measurement of long-acting hormonal contraceptives in plasma via liquid chromatography-tandem mass spectrometry.  |  Knezevic, CE., et al. 2023. J Pharm Biomed Anal. 228: 115321. PMID: 36924631

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Etonogestrel-d7 (Major), 1 mg

sc-218444
1 mg
$380.00