Molecular structure of Etifoxine, CAS Number: 21715-46-8
Etifoxine (CAS 21715-46-8)
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Application:
Etifoxine is a β2 and β3 GABAA receptor agonist
CAS Number:
21715-46-8
Molecular Weight:
300.78
Molecular Formula:
C17H17ClN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Etifoxine is a non-benzodiazepine modulator of GABAergic synaptic transmission described to produce anxiolytic effects. Etifoxine is demonstrated to potentiate GABAA receptor function in cultured neurons through interaction at the B subunit of the receptor, and is shown to evoke a chloride current in the absence of GABA (sc-203053) and to enhance GABA-activated currents.
Etifoxine (CAS 21715-46-8) References
- Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine. | Schlichter, R., et al. 2000. Neuropharmacology. 39: 1523-35. PMID: 10854897
- Effects of etifoxine on ligand binding to GABA(A) receptors in rodents. | Verleye, M., et al. 2002. Neurosci Res. 44: 167-72. PMID: 12354631
- The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit. | Hamon, A., et al. 2003. Neuropharmacology. 45: 293-303. PMID: 12871647
- Etifoxine promotes glia-derived neurite outgrowth in vitro and in vivo. | Dai, T., et al. 2014. J Reconstr Microsurg. 30: 381-8. PMID: 24956483
- Anxiolytics targeting GABAA receptors: Insights on etifoxine. | Poisbeau, P., et al. 2018. World J Biol Psychiatry. 19: S36-S45. PMID: 30204559
- An update on the anxiolytic and neuroprotective properties of etifoxine: from brain GABA modulation to a whole-body mode of action. | Nuss, P., et al. 2019. Neuropsychiatr Dis Treat. 15: 1781-1795. PMID: 31308671
- Etifoxine does not impair muscle tone and motor function in rats as assessed by in vivo and in vitro methods. | Kokova, VY., et al. 2020. Gen Physiol Biophys. 39: 179-186. PMID: 32329445
- TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice. | Zhang, H., et al. 2020. Brain Res Bull. 165: 178-184. PMID: 33075418
- Translocator Protein Ligand Etifoxine Attenuates MPTP-Induced Neurotoxicity. | Tian, Q., et al. 2022. Front Mol Neurosci. 15: 850904. PMID: 35686060
- GABAergic Effects of Etifoxine and Alprazolam Assessed by Double Pulse TMS. | Riebel, M., et al. 2023. Pharmacopsychiatry. 56: 154-161. PMID: 37220781
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TSPO2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Etifoxine, 10 mg | sc-211491 | 10 mg | $320.00 |