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Etidronate Disodium (CAS 7414-83-7)

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Alternate Names:
Didronel; Diphos
Application:
Etidronate Disodium is a bisphosphonate bone resorption inhibitor
CAS Number:
7414-83-7
Purity:
≥98%
Molecular Weight:
249.99
Molecular Formula:
C2H6O7P22Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Etidronate disodium is a compound that functions as a bisphosphonate, inhibiting bone resorption by targeting osteoclast activity. It acts by binding to hydroxyapatite crystals in bone, interfering with their dissolution and preventing the release of calcium ions. This disruption of normal bone turnover leads to a decrease in bone resorption and an increase in bone mineral density. Etidronate disodium also has the ability to chelate with metal ions, such as calcium, and inhibit the formation of calcium phosphate crystals. This dual mechanism of action may be a useful for studying bone metabolism and mineralization processes in experimental models. Etidronate disodium interferes with the function of farnesyl pyrophosphate synthase, an enzyme involved in the mevalonate pathway, ultimately leading to the inhibition of protein prenylation and osteoclast function.


Etidronate Disodium (CAS 7414-83-7) References

  1. Idiopathic calciphylaxis.  |  Banky, JP., et al. 2002. Australas J Dermatol. 43: 190-3. PMID: 12121396
  2. Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia.  |  Gucalp, R., et al. 1992. J Clin Oncol. 10: 134-42. PMID: 1727915
  3. Etidronate: what is its place in treatment of primary osteoporosis and other demineralizing diseases today?  |  Ioachimescu, A. and Licata, A. 2007. Curr Osteoporos Rep. 5: 165-9. PMID: 18430391
  4. Treatment of painful prostatic bone metastases with oral etidronate disodium.  |  Carey, PO. and Lippert, MC. 1988. Urology. 32: 403-7. PMID: 2460988
  5. Effect of etidronate disodium on bone turnover following surgical menopause.  |  Smith, ML., et al. 1989. Calcif Tissue Int. 44: 74-9. PMID: 2492893
  6. Neoplastic hypercalcemia: physiologic response to intravenous etidronate disodium.  |  Jacobs, TP., et al. 1987. Am J Med. 82: 42-50. PMID: 3030098
  7. Etidronate disodium for treating hypercalcaemia of malignancy: a double blind, placebo-controlled study.  |  Hasling, C., et al. 1986. Eur J Clin Invest. 16: 433-7. PMID: 3100312
  8. Effect of etidronate disodium on the interactions between malignancy and bone.  |  Garattini, S., et al. 1987. Am J Med. 82: 29-33. PMID: 3103435
  9. Rapid microwave synthesis of N,S-doped carbon quantum dots as a novel turn off-on sensor for label-free determination of copper and etidronate disodium.  |  El-Malla, SF., et al. 2022. Anal Chim Acta. 1197: 339491. PMID: 35168733
  10. Etidronate disodium in the treatment of Paget's disease of bone.  |  Krane, SM. 1982. Ann Intern Med. 96: 619-25. PMID: 6280538
  11. Etidronate disodium in postmenopausal osteoporosis.  |  Heaney, RP. and Saville, PD. 1976. Clin Pharmacol Ther. 20: 593-604. PMID: 824086
  12. The effects of etidronate disodium on progressive hearing loss from otosclerosis.  |  Kennedy, DW., et al. 1993. Otolaryngol Head Neck Surg. 109: 461-7. PMID: 8414563
  13. Effects of etidronate disodium on crystallizations in synthetic urine and calcium oxalate crystal adhesion to Madin-Darby canine kidney (MDCK) cells.  |  Ebisuno, S., et al. 1998. Int J Urol. 5: 582-7. PMID: 9855128

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Etidronate Disodium, 1 g

sc-205687
1 g
$127.00

Etidronate Disodium, 5 g

sc-205687A
5 g
$490.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Etidronate Disodium, sc-205687, is a white solid.
Answered by: TechService7
Date published: 2017-01-27
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Rated 5 out of 5 by from Li et alLi et al. (Pubmed ID 25607347) found that Etidronate Disodium significantly reduced ectopic soft tissue mineralization caused by ABCC6 gene mutations. -SCBT Publication Review
Date published: 2015-02-05
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Etidronate Disodium is rated 5.0 out of 5 by 1.
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