Date published: 2026-4-27

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Ethynyl p-tolyl sulfone (CAS 13894-21-8)

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Alternate Names:
p-Toluenesulfonylacetylene; Tosylacetylene
CAS Number:
13894-21-8
Molecular Weight:
180.22
Molecular Formula:
C9H8O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethynyl p-tolyl sulfone is a compound that functions as a strong electrophile due to the presence of the ethynyl group. It is known to react with various nucleophiles, such as amines and thiols, through addition reactions. Ethynyl p-tolyl sulfone′s mechanism of action involves the formation of covalent bonds with nucleophilic functional groups, leading to the modification of biomolecules or intermediates. Ethynyl p-tolyl sulfone has been utilized in development applications for its ability to introduce specific functional groups into organic molecules, allowing for the synthesis of complex compounds. Its reactivity and selectivity make it a useful for the modification of target molecules in chemical synthesis and material science applications. Its unique structure enables it to participate in diverse chemical transformations, making it a versatile building block for the construction of complex molecular architectures.


Ethynyl p-tolyl sulfone (CAS 13894-21-8) References

  1. Efficient and practical method for synthesizing optically active indan-2-ols by the Ti(O-i-Pr)(4)/2 i-PrMgCl-mediated metalative Reppe reaction.  |  Hanazawa, T., et al. 2003. J Org Chem. 68: 4980-3. PMID: 12790616
  2. Tosvinyl and besvinyl as protecting groups of imides, azinones, nucleosides, sultams, and lactams. Catalytic conjugate additions to tosylacetylene.  |  Petit, E., et al. 2014. J Org Chem. 79: 8826-34. PMID: 25162376

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethynyl p-tolyl sulfone, 1 g

sc-239974
1 g
$127.00