Date published: 2025-9-21

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Ethynyl Estradiol (CAS 57-63-6)

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Alternate Names:
17α-Ethynylestradiol; 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol; 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol
Application:
Ethynyl Estradiol is a synthetic estradiol analog
CAS Number:
57-63-6
Molecular Weight:
296.4
Molecular Formula:
C20H24O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethynyl Estradiol serves as a synthetic estrogen hormone. Classified as a phenolic compound, it represents a non-steroidal estrogen where an ethinyl group is attached to the 17-beta position of estradiol. Ethynyl Estradiol stands as one of the most extensively studied and widely used synthetic estrogens worldwide, finding application in various scientific research realms. The functionality of Ethynyl Estradiol lies in its ability to bind to estrogen receptors.


Ethynyl Estradiol (CAS 57-63-6) References

  1. Effect of ethynyl estradiol on the secretion of hepatic triglyceride.  |  Weinstein, I., et al. 1975. Proc Soc Exp Biol Med. 149: 181-4. PMID: 1144424
  2. Treatment of menstrual disorders with a combination of norgestrel and ethynyl estradiol.  |  Rao, KP. 1971. Curr Med Pract. 15: 586-9. PMID: 12306340
  3. Radioimmunoassay of norethindrone (17 alpha-ethynyl-17 beta-hydroxy-4-estren-3-one) and ethynyl-estradiol (17 alpha-ethynyl-1,3,5, (10)-estratien-3, 17 beta-diol). Application to human plasma determination of norethindrone after oral administration of this steroid.  |  Pasqualini, JR., et al. 1975. Reproduccion. 2: 197-205. PMID: 1232004
  4. Temporal changes in gene expression in rainbow trout exposed to ethynyl estradiol.  |  Hook, SE., et al. 2007. Comp Biochem Physiol C Toxicol Pharmacol. 145: 73-85. PMID: 17215170
  5. Contraceptive devices: intravaginal and intrauterine delivery systems.  |  Benagiano, G., et al. 2008. Expert Rev Med Devices. 5: 639-54. PMID: 18803474
  6. Effect of methyl testosterone- and ethynyl estradiol-induced sex differentiation on catfish, Clarias gariepinus: expression profiles of DMRT1, Cytochrome P450aromatases and 3 beta-hydroxysteroid dehydrogenase.  |  Raghuveer, K., et al. 2005. Fish Physiol Biochem. 31: 143-7. PMID: 20035448
  7. The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats.  |  Vega Rivera, NM., et al. 2016. Pharmaceuticals (Basel). 9: PMID: 27153072
  8. Perspectives on growth promoting treatment for patients with Turner syndrome in Japan.  |  Tanaka, T. 2020. Clin Pediatr Endocrinol. 29: 91-97. PMID: 32694884
  9. [Effect of ethynyl estradiol and estradiol dipropionate on the esterification of saturated and unsaturated fatty acids in the rat liver].  |  Sanfirova, VM., et al. 1987. Vopr Med Khim. 33: 77-83. PMID: 3604148
  10. Metabolism of ethynyl estrogens.  |  Helton, ED. and Goldzieher, JW. 1977. J Toxicol Environ Health. 3: 231-41. PMID: 411942
  11. Ethynyl estradiol content of cervical mucus after administration of oral contraceptive.  |  Morvay, J., et al. 1983. Horm Res. 18: 221-4. PMID: 6642427
  12. Intrahepatic cholestasis and hyperbilirubinemia in ethynyl estradiol and chlorpromazine-treated rats.  |  Obata, T. 1983. Gastroenterol Jpn. 18: 538-48. PMID: 6671512
  13. Alterations of plasma HDL lipids and apolipoproteins in female rats treated with ethynyl estradiol.  |  Wilcox, HG., et al. 1981. Biochim Biophys Acta. 666: 348-55. PMID: 7326248

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethynyl Estradiol, 100 mg

sc-205318
100 mg
$20.00

Ethynyl Estradiol, 500 mg

sc-205318A
500 mg
$28.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Ethynyl Estradiol, sc-205318, is in white or creamy white crystalline powder form.
Answered by: Chemical Support 4
Date published: 2017-07-03
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Rated 5 out of 5 by from Ethynyl Estradiol was reported as a syntheticEthynyl Estradiol was reported as a synthetic analog of estradiol that can be absorbed in the gastrointestial tract. -SCBT Publication Review
Date published: 2015-04-15
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Ethynyl Estradiol is rated 5.0 out of 5 by 1.
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