Date published: 2026-1-30

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Ethylene-d4 glycol (CAS 2219-51-4)

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Application:
Ethylene-d4 glycol is an isotopically labeled analog of Ethylene Glycol
CAS Number:
2219-51-4
Molecular Weight:
66.09
Molecular Formula:
C2D4H2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethylene-d4 glycol is a deuterated form of ethylene glycol. It is an organic compound that consists of two deuterium atoms replacing two hydrogen atoms in the ethylene glycol molecule. This deuterium labeling provides unique properties that make it valuable in various scientific applications. Ethylene-d4 glycol has several scientific applications, particularly in the field of chemistry. It serves as a versatile solvent and a starting material for organic syntheses. The deuterium labeling offered by ethylene-d4 glycol enables the tracking and identification of molecules in complex systems, allowing researchers to study reaction mechanisms, kinetics, and the behavior of molecules in biological systems. It is used in studies that employ techniques such as nuclear magnetic resonance (NMR) spectroscopy. Furthermore, ethylene-d4 glycol finds application in pharmaceutical research. It serves as a stable isotopic internal standard in drug metabolism studies and pharmacokinetic investigations. By using ethylene-d4 glycol as a reference compound, researchers can accurately measure the absorption, distribution, metabolism, and excretion of drugs in living organisms. This information aids in understanding drug efficacy, toxicity, and interactions with biological systems. In terms of its mechanism of action, ethylene-d4 glycol shares similar properties and reactivity with ethylene glycol. It acts as a diol, featuring two hydroxyl groups, which allows it to participate in various chemical reactions. It can undergo esterification, ether formation, and oxidation reactions, among others. These reactivity patterns contribute to its usefulness in organic synthesis and as a solvent in different scientific and industrial applications.


Ethylene-d4 glycol (CAS 2219-51-4) References

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  2. Headspace in-tube extraction gas chromatography-mass spectrometry for the analysis of hydroxylic methyl-derivatized and volatile organic compounds in blood and urine.  |  Rasanen, I., et al. 2010. J Anal Toxicol. 34: 113-21. PMID: 20406534
  3. Validation of a rapid, automated method for the measurement of ethylene glycol in human plasma.  |  Robson, AF., et al. 2017. Ann Clin Biochem. 54: 481-489. PMID: 27538769
  4. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels.  |  Williams, KC., et al. 2018. J Pediatr. 195: 148-153.e1. PMID: 29395181
  5. Ru supported on MnBCD derived from Mn MOF for thermo- and electro-catalytic synthesis of ethylene-d4 glycol.  |  Shao, F., et al. 2023. ChemSusChem. e202202395. PMID: 37012670
  6. Calculated and Measured 13C NMR Chemical Shifts of the 2, 4, 6-Trichloroheptanes and Their Implications for the 13C NMR Spectra of Poly (vinyl chloride)  |  Tonelli, A. E., et al. 1979. Macromolecules. 12: 78-83.
  7. MR relaxation in poly (butylene terephthalate) and poly (butylene terephthalate) containing segmented copolymers. 5.  |  Jelinski, Lynn W., et al. 1983. Macromolecules. 16: 409-415.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethylene-d4 glycol, 1 g

sc-228089
1 g
$199.00