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Ethyl salicylate (CAS 118-61-6)

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Alternate Names:
Ethyl 2-hydroxybenzoate
CAS Number:
118-61-6
Molecular Weight:
166.17
Molecular Formula:
C9H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethyl salicylate, or salicylic acid ethyl ester, is a delightful aromatic compound obtained from salicylic acid and ethyl alcohol. This colorless, thick liquid emits a sweet, floral fragrance, making it an essential ingredient in perfumes, food flavorings, and pharmaceuticals. Moreover, it serves as a preservative, antifungal, and insect repellent. In the realm of scientific research, ethyl salicylate finds extensive applications. Scientists explore its biochemical and physiological effects and investigate its potential for drug delivery systems. It also acts as a model compound for studying the characteristics of other esters. What sets ethyl salicylate apart is its ability to inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, critical players in the production of prostaglandins and other inflammatory mediators. Additionally, it acts as an inhibitor of acetylcholinesterase, an enzyme responsible for the breakdown of acetylcholine. This multifaceted compound opens up exciting avenues in the world of science and industry.


Ethyl salicylate (CAS 118-61-6) References

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  2. Fragrance material review on ethyl salicylate.  |  Lapczynski, A., et al. 2007. Food Chem Toxicol. 45 Suppl 1: S397-401. PMID: 18023517
  3. Encapsulation of methyl and ethyl salicylates by beta-cyclodextrin HPLC, UV-vis and molecular modeling studies.  |  Filippa, M., et al. 2008. J Pharm Biomed Anal. 48: 969-73. PMID: 18650048
  4. On-line reaction monitoring by extractive electrospray ionisation.  |  McCullough, BJ., et al. 2011. Rapid Commun Mass Spectrom. 25: 1445-51. PMID: 21504011
  5. Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.  |  Pauwels, J., et al. 2012. J Pharm Biomed Anal. 60: 51-8. PMID: 22094014
  6. Plasticized branched aliphatic oligoesters as potential mucoadhesive drug carriers.  |  Snejdrova, E., et al. 2013. Int J Pharm. 458: 282-6. PMID: 24183958
  7. Estimating Maximal In Vitro Skin Permeation Flux from Studies Using Non-sink Receptor Phase Conditions.  |  Yousef, S., et al. 2016. Pharm Res. 33: 2180-94. PMID: 27312087
  8. Mechanistic Evaluation of Hydration Effects on the Human Epidermal Permeation of Salicylate Esters.  |  Yousef, S., et al. 2017. AAPS J. 19: 180-190. PMID: 27634383
  9. An improvement of LLNA:DA to assess the skin sensitization potential of chemicals.  |  Zhang, H., et al. 2017. J Toxicol Sci. 42: 129-136. PMID: 28321039
  10. Enhancing the stability of a carboxylesterase by entrapment in chitosan coated alginate beads.  |  Raghu, S. and Pennathur, G. 2018. Turk J Biol. 42: 307-318. PMID: 30814894
  11. Signaling in the Tomato Immunity against Fusarium oxysporum.  |  Hernández-Aparicio, F., et al. 2021. Molecules. 26: PMID: 33804901
  12. Volatile Constituent Analysis of Wintergreen Essential Oil and Comparison with Synthetic Methyl Salicylate for Authentication.  |  Ojha, PK., et al. 2022. Plants (Basel). 11: PMID: 35448818
  13. Simultaneous quantitative analysis of methyl salicylate, ethyl salicylate and salicylic acid from biological fluids using gas chromatography-mass spectrometry.  |  Kakkar, T. and Mayersohn, M. 1998. J Chromatogr B Biomed Sci Appl. 718: 69-75. PMID: 9832362

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethyl salicylate, 100 g

sc-239949
100 g
$30.00