Date published: 2025-12-5

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Ethyl methanesulfonate (CAS 62-50-0)

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Alternate Names:
Ethyl mesylate
Application:
Ethyl methanesulfonate is a DNA ethylating mutagenic agent
CAS Number:
62-50-0
Purity:
99%
Molecular Weight:
124.16
Molecular Formula:
C3H8O3S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethyl methanesulfonate (EMS) is a chemical compound with the molecular formula C3H8SO3. It is an alkylating agent used in mutagenesis studies and genetic research. Ethyl methanesulfonate is known for its ability to induce mutations in DNA by alkylating nucleotides, leading to changes in the genetic information. It is often used to create specific mutations in organisms to study the effects on gene function and phenotype.


Ethyl methanesulfonate (CAS 62-50-0) References

  1. Ethyl methanesulfonate-induced reversion of bacteriophage T4rII mutants.  |  KRIEG, DR. 1963. Genetics. 48: 561-80. PMID: 14035786
  2. Physical and chemical mutagenesis.  |  Kodym, A. and Afza, R. 2003. Methods Mol Biol. 236: 189-204. PMID: 14501066
  3. Mutagenic Action of Ethyl Methanesulfonate in Maize.  |  Neuffer, MG. and Ficsor, G. 1963. Science. 139: 1296-7. PMID: 17757068
  4. The Viracept (nelfinavir)--ethyl methanesulfonate case: a threshold risk assessment for human exposure to a genotoxic drug contamination?  |  Lutz, WK. 2009. Toxicol Lett. 190: 239-42. PMID: 19695319
  5. Interspecific comparison of ethyl methanesulfonate-induced mutation rates in relation to genome size.  |  Schalet, AP. 1978. Mutat Res. 49: 313-40. PMID: 204867
  6. Ethyl methanesulfonate induces mutations in Caenorhabditis elegans embryos at a high frequency.  |  Hartman, PS., et al. 2014. Mutat Res. 766-767: 44-8. PMID: 25847271
  7. Determination of methyl methanesulfonate and ethyl methanesulfonate in methanesulfonic acid by derivatization followed by high-performance liquid chromatography with ultraviolet detection.  |  Zhou, J., et al. 2017. J Sep Sci. 40: 3414-3421. PMID: 28675589
  8. Ethyl Methanesulfonate Mutagenesis in Schizosaccharomyces pombe.  |  Ekwall, K. and Thon, G. 2017. Cold Spring Harb Protoc. 2017: pdb.prot091736. PMID: 28765296
  9. artMAP: A user-friendly tool for mapping ethyl methanesulfonate-induced mutations in Arabidopsis.  |  Javorka, P., et al. 2019. Plant Direct. 3: e00146. PMID: 31245783
  10. EMS Mutagenesis of Arabidopsis Seeds.  |  Gillmor, CS. and Lukowitz, W. 2020. Methods Mol Biol. 2122: 15-23. PMID: 31975292
  11. Ethyl methanesulfonate mutant library construction in Gossypium hirsutum L. for allotetraploid functional genomics and germplasm innovation.  |  Lian, X., et al. 2020. Plant J. 103: 858-868. PMID: 32239588
  12. An ethyl methanesulfonate-induced neutral mutant-bridging method efficiently identifies spontaneously mutated genes in rice.  |  Hu, W., et al. 2020. Plant J. 104: 1129-1141. PMID: 32808346
  13. A review of the genetic effects of ethyl methanesulfonate.  |  Sega, GA. 1984. Mutat Res. 134: 113-42. PMID: 6390190

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethyl methanesulfonate, 1 g

sc-257504
1 g
$33.00

Ethyl methanesulfonate, 5 g

sc-257504A
5 g
$42.00

Ethyl methanesulfonate, 25 g

sc-257504B
25 g
$64.00

Ethyl methanesulfonate, 100 g

sc-257504C
100 g
$206.00

Ethyl methanesulfonate, 500 g

sc-257504D
500 g
$526.00