Date published: 2025-11-23

1-800-457-3801

SCBT Portrait Logo
Seach Input

Ethyl chlorooxoacetate (CAS 4755-77-5)

0.0(0)
Write a reviewAsk a question

Alternate Names:
Ethyl chloroglyoxylate; Monoethyl oxalyl chloride; Oxalic acid monoethyl ester chloride; mono-Ethyl oxalyl chloride
CAS Number:
4755-77-5
Purity:
≥98%
Molecular Weight:
136.53
Molecular Formula:
C4H5ClO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ethyl chlorooxoacetate is a chemical compound that functions as an acylation reagent in organic synthesis. It acts as an electrophile, reacting with nucleophiles such as amines, alcohols, and thiols to form esters, amides, and thioesters, respectively. The mode of action involves the transfer of the acyl group to the nucleophile, resulting in the formation of the desired acylated product. Ethyl chlorooxoacetate is known for its ability to efficiently acylate a wide range of nucleophiles, making it versatile in the synthesis of various organic compounds. Its reactivity and selectivity in acylation reactions make it an in the development of new molecules and materials. In the development, plays a role in the modification of functional groups and the creation of diverse chemical structures.


Ethyl chlorooxoacetate (CAS 4755-77-5) References

  1. Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors.  |  Lee, KS., et al. 2005. Bioorg Med Chem Lett. 15: 2857-60. PMID: 15911268
  2. Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.  |  Dudash, J., et al. 2005. Bioorg Med Chem Lett. 15: 4790-3. PMID: 16143521
  3. Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase.  |  Choi, SR., et al. 2007. J Comb Chem. 9: 292-300. PMID: 17316052
  4. An efficient and scalable synthesis of substituted phenanthrenequinones by intramolecular Friedel-Crafts reaction of imidazolides.  |  Yoshikawa, N., et al. 2007. Org Lett. 9: 4103-6. PMID: 17880225
  5. Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.  |  Meanwell, NA., et al. 2009. Bioorg Med Chem Lett. 19: 1977-81. PMID: 19251416
  6. Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.  |  Kim, KJ., et al. 2014. Bioorg Med Chem Lett. 24: 1958-62. PMID: 24656662
  7. 2,2,2-Trifluoroethyl Chlorooxoacetate--Universal Reagent for One-Pot Parallel Synthesis of N(1)-Aryl-N(2)-alkyl-Substituted Oxamides.  |  Bogolubsky, AV., et al. 2015. ACS Comb Sci. 17: 615-22. PMID: 26325360
  8. Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist.  |  Barber, DM., et al. 2017. Chem Sci. 8: 611-615. PMID: 28451208
  9. Introducing an α-Keto Ester Functional Group through Pt-Catalyzed Direct C-H Acylation with Ethyl Chlorooxoacetate.  |  Javed, E., et al. 2020. ACS Omega. 5: 8393-8402. PMID: 32309750
  10. Rhodium(I)-NHC Complexes Bearing Bidentate Bis-Heteroatomic Acidato Ligands as gem-Selective Catalysts for Alkyne Dimerization.  |  Galiana-Cameo, M., et al. 2020. Chemistry. 26: 9598-9608. PMID: 32374897
  11. A2B- and A3-Type Boron(III)Subchlorins Derived from meso-Diethoxycarbonyltripyrrane: Synthesis and Photophysical Exploration.  |  Soman, R., et al. 2021. J Org Chem. 86: 10280-10287. PMID: 34264670
  12. Efficient access to aliphatic esters by photocatalyzed alkoxycarbonylation of alkenes with alkyloxalyl chlorides.  |  Chen, JQ., et al. 2021. Nat Commun. 12: 5328. PMID: 34493725
  13. Synthesis of Ester-Substituted Indolo[2,1-a]isoquinolines via Photocatalyzed Alkoxycarbonylation/Cyclization Reactions.  |  Chen, JQ., et al. 2022. Org Lett. 24: 642-647. PMID: 34985296
  14. Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation.  |  Koul, S., et al. 2022. Bioorg Med Chem Lett. 62: 128632. PMID: 35189320
  15. Visible-Light-Induced 1,7-Enyne Dicyclization: Synthesis of Ester-Substituted Benzo[j]phenanthridines.  |  Chen, JQ., et al. 2023. Org Lett. 25: 1978-1983. PMID: 36912498

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethyl chlorooxoacetate, 25 g

sc-239923
25 g
$35.00

Ethyl chlorooxoacetate, 100 g

sc-239923A
100 g
$85.00