Ethyl acetoacetate (CAS 141-97-9)

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Alternate Names:

Acetoacetic ester

CAS Number:

141-97-9

Molecular Weight:

130.14

Molecular Formula:

C₆H₁₀O₃

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data.

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Ethyl acetoacetate is a versatile compound that functions as a β-keto ester in various chemical reactions. It serves as a fundamental building block for the synthesis of a wide range of organic compounds, including agrochemicals, dyes, and other bioactive substances. Its mechanism of action involves participating in Claisen condensation reactions, Michael additions, and Knoevenagel condensations, leading to the formation of complex molecules with multiple functional groups. Ethyl acetoacetate′s reactivity at the α-carbon position allows for the introduction of diverse substituents, enabling the creation of structurally diverse compounds.

Ethyl acetoacetate (CAS 141-97-9) References

9-Eth-oxy-1,5,13-trimethyl-8,10-dioxa-tetra-cyclo-[7.7.1.0.0]hepta-deca-2,4,6,11,13,15-hexa-ene. | Nowakowska-Bogdan, EM., et al. 2009. Acta Crystallogr Sect E Struct Rep Online. 65: o2228. PMID: 21577627
Ethyl 6-(4-ethoxy-phen-yl)-4-(furan-2-yl)-2-oxocyclo-hex-3-ene-1-carboxyl-ate. | Badshah, A., et al. 2008. Acta Crystallogr Sect E Struct Rep Online. 65: o70. PMID: 21581709
Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate. | Bai, MS., et al. 2009. Acta Crystallogr Sect E Struct Rep Online. 65: o799. PMID: 21582523
Ethyl 6-(6-meth-oxy-2-naphth-yl)-2-oxo-4-(2-thien-yl)cyclo-hex-3-ene-1-carboxyl-ate. | Li, H., et al. 2009. Acta Crystallogr Sect E Struct Rep Online. 65: o1533. PMID: 21582822
3,5-Bis(ethoxy-carbon-yl)-2,6-dimethyl-1,4-dihydro-pyridine-4-carboxylic acid. | Wu, DH. and Hu, L. 2009. Acta Crystallogr Sect E Struct Rep Online. 65: o1748. PMID: 21583459
Ethyl 3-[2-(p-tolyl-carbamothio-yl)hydrazinyl-idene]butano-ate. | Zhang, YL., et al. 2010. Acta Crystallogr Sect E Struct Rep Online. 66: o2971. PMID: 21589138
Diethyl 4-(4-acetamido-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate. | Zhao, Y., et al. 2012. Acta Crystallogr Sect E Struct Rep Online. 68: o2536. PMID: 22904969
A novel method for quantitative analysis of acetylacetone and ethyl acetoacetate by fluorine-19 nuclear magnetic spectroscopy. | Zhou, L., et al. 2016. Magn Reson Chem. 54: 222-6. PMID: 26521683
Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm. | Horne, SM., et al. 2018. Lett Appl Microbiol. 66: 329-339. PMID: 29341217
The keto-enol tautomerization of ethyl acetoacetate in choline ionic liquids: the role of cation and anion in switching the tautomeric equilibrium. | Kumar, MD. and Jaccob, M. 2021. Phys Chem Chem Phys. 23: 7386-7397. PMID: 33876098
The Food Anti-Microbials β-Phenylethylamine (-HCl) and Ethyl Acetoacetate Do Not Change during the Heating Process. | Horne, SM., et al. 2021. Antibiotics (Basel). 10: PMID: 33920266
Synthesis and Antiplatelet Activity Evaluation of a Group of Novel Ethyl Acetoacetate Phenylhydrazone Derivatives. | Farhady, S., et al. 2021. Iran J Pharm Res. 20: 307-315. PMID: 34567164
A Wash of Ethyl Acetoacetate Reduces Externally Added Salmonella enterica on Tomatoes. | Horne, SM. and Prüß, BM. 2022. Antibiotics (Basel). 11: PMID: 36010003
Ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity. | Gajjala, RR., et al. 2022. Bioorg Chem. 129: 106205. PMID: 36265354
Ethyl acetoacetate and acetylacetone appended hexabromo porphyrins: synthesis, spectral, electrochemical, and femtosecond third-order nonlinear optical studies. | Rohal, RK., et al. 2023. Dalton Trans. 52: 5523-5533. PMID: 37005971

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Product Name	Catalog #	UNIT	Price	Qty		FAVORITES
Ethyl acetoacetate, 100 ml	sc-239917	100 ml	$48.00

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Test	Specification	Results
Appearance	Colorless clear liquid	Complies
Identification (¹H-NMR)	Consistent with structure	Complies
Purity (GC)	≥ 99.0%	99.7%
Trace metal analysis	Consistent with requirement	Complies
Refractive Index (n20/D)	1.418 - 1.420	1.419
Aluminum	≤ 0.5 mg/kg (ICP)	< 0.5 mg/kg
Barium	≤ 0.1 mg/kg (ICP)	< 0.1 mg/kg
Bismuth	≤ 0.1 mg/kg (ICP)	< 0.1 mg/kg
Cadmium	≤ 0.05 mg/kg (ICP)	< 0.05 mg/kg
Calcium (ICP)	≤ 0.5 mg/kg	< 0.5 mg/kg
Chromium	≤ 0.02 mg/kg (ICP)	< 0.02 mg/kg
Cobalt	≤ 0.02 mg/kg (ICP)	< 0.02 mg/kg
Copper	≤ 0.02 mg/kg (ICP)	< 0.02 mg/kg
Iron (ICP)	≤ 0.1 mg/kg	< 0.1 mg/kg
Lead (ICP)	≤ 0.1 mg/kg	< 0.1 mg/kg
Lithium	≤ 0.1 mg/kg (ICP)	< 0.1 mg/kg
Magnesium	≤ 0.1 mg/kg (ICP)	< 0.1 mg/kg
Manganese	≤ 0.02 mg/kg (ICP)	< 0.02 mg/kg
Molybdenum	≤ 0.1 mg/kg (ICP)	< 0.1 mg/kg
Nickel	≤ 0.02 mg/kg (ICP)	< 0.02 mg/kg
Potassium (ICP)	≤ 0.5 mg/kg	< 0.5 mg/kg
Sodium (ICP)	≤ 0.5 mg/kg	< 0.5 mg/kg
Strontium	≤ 0.1 mg/kg (ICP)	< 0.1 mg/kg
Water Content	≤ 0.5%	0.01%
Zinc	≤ 0.5 mg/kg (ICP)	< 0.5 mg/kg

Ethyl acetoacetate (CAS 141-97-9)

Ethyl acetoacetate (CAS 141-97-9) References

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Ethyl acetoacetate, 100 ml