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Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (CAS 141573-95-7)

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Alternate Names:
3-Difluoromethyl-1-methylpyrazole-4-carboxylic Acid Ethyl Ester
CAS Number:
141573-95-7
Purity:
≥98%
Molecular Weight:
204.17
Molecular Formula:
C8H10F2N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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EFMC, or Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, is a used organic compound in scientific research and laboratory experiments. As a chiral compound, it has two enantiomers, which are used in organic synthesis to control the stereochemistry of the reaction. Moreover, Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate can promote chemical reactions without being consumed in the process, acting as a chiral catalyst. Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate has been applied to synthesize chiral compounds like amino acids and peptides, as well as polymers and other materials. By acting as a chiral auxiliary, Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate binds to the substrate and directs the reaction to favor one enantiomer over the other, resulting in stereoselectivity.


Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (CAS 141573-95-7) References

  1. Synthesis, nematocidal activity and SAR study of novel difluoromethylpyrazole carboxamide derivatives containing flexible alkyl chain moieties.  |  Liu, XH., et al. 2017. Eur J Med Chem. 125: 881-889. PMID: 27769029
  2. Design, synthesis, and antifungal activity of novel cinnamon-pyrazole carboxamide derivatives.  |  Ren, ZL., et al. 2018. Drug Dev Res. 79: 307-312. PMID: 30256430
  3. Rational Exploration of Novel SDHI Fungicide through an Amide-β-ketonitrile Bioisosteric Replacement Strategy.  |  Zhou, C., et al. 2023. J Agric Food Chem. 71: 5483-5495. PMID: 36975160
  4. An Atom-Efficient Route to Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (DFMMP)-A Key Building Block for a Novel Fungicide Family  |  Janis Jaunzems* and Max Braun*. 2014. Organic Process Research & Development. 18: 1055–1059.
  5. Chapter 10 - Microwave-assisted synthesis of fluoroorganics  |  Ana Maria M.M. Faisca Phillips, Armando J.L. Pombeiro. 2021. Green Sustainable Process for Chemical and Environmental Engineering and Science. 415-488.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, 1 g

sc-263221
1 g
$144.00

Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, 5 g

sc-263221A
5 g
$422.00