Date published: 2025-12-6

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Ethyl 2,4-dichloropyrimidine-5-carboxylate (CAS 51940-64-8)

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CAS Number:
51940-64-8
Molecular Weight:
221.04
Molecular Formula:
C7H6Cl2N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethyl 2,4-dichloropyrimidine-5-carboxylate finds diverse applications in scientific research and has been instrumental in the development of novel materials and processes. Its role extends to the synthesis of various compounds, including nucleoside analogues. While the precise mechanism of action of Ethyl 2,4-dichloropyrimidine-5-carboxylate is not fully elucidated, it is known to be a nucleophilic compound capable of engaging in reactions with other molecules to generate new compounds.


Ethyl 2,4-dichloropyrimidine-5-carboxylate (CAS 51940-64-8) References

  1. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives.  |  Hisamichi, H., et al. 2005. Bioorg Med Chem. 13: 4936-51. PMID: 15990316
  2. Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors.  |  Nagashima, S., et al. 2007. Bioorg Med Chem. 15: 1044-55. PMID: 17071093
  3. Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors.  |  Nagashima, S., et al. 2008. Bioorg Med Chem. 16: 6509-21. PMID: 18534856
  4. Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors.  |  Hao, Y., et al. 2017. Sci Rep. 7: 3830. PMID: 28630494
  5. Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors.  |  Cui, G., et al. 2018. Bioorg Med Chem. 26: 2186-2197. PMID: 29576270
  6. Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.  |  Hao, Y., et al. 2018. J Med Chem. 61: 5609-5622. PMID: 29906114
  7. Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.  |  Fromont, C., et al. 2020. J Med Chem. 63: 6784-6801. PMID: 32433887
  8. Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.  |  Yuan, Y., et al. 2021. J Med Chem. 64: 13572-13587. PMID: 34496560
  9. Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.  |  Wong, SW., et al. 2021. Eur J Med Chem. 226: 113822. PMID: 34563964
  10. Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease.  |  Yang, T., et al. 2022. J Med Chem. 65: 3151-3172. PMID: 35113547
  11. Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines.  |  Monier, M., et al. 2019. RSC Adv. 9: 30835-30867. PMID: 35558733
  12. Pyrimido[4,5-d]pyrimidin-4(1H)-one Derivatives as Selective Inhibitors of EGFR Threonine790 to Methionine790 (T790M) Mutants  |  Xu, T., Zhang, L., Xu, S., Yang, C. Y., Luo, J., Ding, F.,.. & Ding, K. 2013. Angewandte Chemie. 125(32): 8545-8548.
  13. The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor  |  Goldberg, F. W., Finlay, M. R. V., Ting, A. K., Beattie, D., Lamont, G. M., Fallan, C.,.. & Dean, E. 2019. J. Med. Chem. 63(7): 3461–3471.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethyl 2,4-dichloropyrimidine-5-carboxylate, 1 g

sc-482226
1 g
$35.00