Ethaverine (CAS 486-47-5)
Alternate Names:
Perparine; Barbonin; Dyscural
CAS Number:
486-47-5
Molecular Weight:
395.49
Molecular Formula:
C24H29NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ethaverine, also referred to as ethaverin or ethaverinum, serves as a synthetic compound employed in laboratory experiments to explore the influence of calcium on biological processes. Its mode of action involves impeding the entry of calcium ions into cells. This is accomplished by binding to the calcium ion channels, thereby hindering the passage of calcium ions through the cell membrane. By binding to these channels, ethaverine not only blocks calcium influx but also thwarts the activation of other calcium-dependent processes, including cell signaling pathways.
Ethaverine (CAS 486-47-5) References
- Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei. | Zoraghi, R., et al. 2001. J Biol Chem. 276: 11559-66. PMID: 11134002
- Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. | Shin, JS., et al. 2001. Biol Pharm Bull. 24: 103-5. PMID: 11201237
- Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. | Lee, SS., et al. 2001. Biol Pharm Bull. 24: 838-40. PMID: 11456127
- [Comparative activity of ethaverine and papaverine on the effective refractory period of the isolated guinea pig atrium]. | Lacroix, P., et al. 1977. C R Seances Soc Biol Fil. 171: 214-7. PMID: 143322
- Papaverine analogs. 8. Comparative actions of papaverine, ethaverine and dioxyline on the cardiovascular system. | HANNA, C. and PARKER, RC. 1960. Arch Int Pharmacodyn Ther. 126: 386-92. PMID: 14399525
- Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. | Wang, Y. and Rosenberg, RL. 1991. Mol Pharmacol. 40: 750-5. PMID: 1658607
- Determination of ethaverine and papaverine using ion-selective electrodes. | Eppelsheim, C., et al. 1991. Analyst. 116: 1001-3. PMID: 1801598
- Apigenin and Ethaverine Hydrochloride Enhance Retinal Vascular Barrier In Vitro and In Vivo. | Jiang, W., et al. 2020. Transl Vis Sci Technol. 9: 8. PMID: 32821505
- Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach. | Hosseini, FS., et al. 2022. Res Pharm Sci. 17: 540-557. PMID: 36386482
- Letter: Ethaverine therapy for multiple leiomyomas. | Frankel, EB. 1974. Arch Dermatol. 110: 296. PMID: 4852780
- Heterogeneity of biochemical actions among vasodilators. | Greenslade, FC., et al. 1982. J Pharm Sci. 71: 94-100. PMID: 6276530
- Determination of the antispasmodic agent ethaverine in human plasma by high-performance liquid chromatography. | Brodie, RR., et al. 1980. J Chromatogr. 182: 379-86. PMID: 7391180
- Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. | Suh, BC. and Kim, KT. 1994. Biochem Pharmacol. 47: 1262-6. PMID: 8161356
- Ion-pair reversed-phase liquid chromatographic identification and quantitation of papaverine congeners. | Girgis, EH. 1993. J Pharm Sci. 82: 503-5. PMID: 8360827
- [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. | Lacroix, P., et al. 1976. Arch Int Pharmacodyn Ther. 221: 163-76. PMID: 962426
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ethaverine, 10 mg | sc-499117 | 10 mg | $380.00 |