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Ethanol-2,2,2-d3 (CAS 1759-87-1)

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Alternate Names:
Ethyl alcohol-2,2,2-d3
CAS Number:
1759-87-1
Molecular Weight:
49.09
Molecular Formula:
C2D3H3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethanol-2,2,2-d3, also referred to as 2,2,2-trideuterioethanol, is a specialized compound used in research to investigate the metabolic processes of ethanol. This isotopically labeled ethanol is categorized as a deuterated compound due to the presence of deuterium, a heavier isotope of hydrogen, within its structure. Deuterium, occurring in small quantities in nature, is employed in scientific studies to explore biochemical and metabolic pathways. Ethanol-2,2,2-d3 plays a role in research focused on understanding ethanol metabolism. Moreover, it enables the study of alcohol metabolism for other alcohols such as methanol and propanol. The metabolism of ethanol-2,2,2-d3 closely resembles that of regular ethanol. Initially, the deuterium-labeled ethanol undergoes oxidation by alcohol dehydrogenase, resulting in the formation of acetaldehyde-2,2,2-d3. Subsequently, aldehyde dehydrogenase further oxidizes acetaldehyde-2,2,2-d3 to yield acetate-2,2,2-d3. Finally, the citric acid cycle metabolizes acetate-2,2,2-d3, ultimately producing carbon dioxide and water.


Ethanol-2,2,2-d3 (CAS 1759-87-1) References

  1. Hydrogen rearrangements of ionized propanoic acid and isomeric ions  |  McAdoo, D. J., & Witiak, D. N. 1978. Organic Mass Spectrometry. 13(9): 499-503.
  2. Reactions of coordinatively unsaturated cobalt-alkene complexes generated by metal atom condensation techniques  |  Locke, S. A., & Shevlin, P. B. 1984. Organometallics. 3(2): 217-222.
  3. The orientations and dynamics of ethanol guest molecules in the clathrate of Dianin's compound: A 2H-nuclear magnetic resonance single crystal study  |  Bernhard, T., Zimmermann, H., & Haeberlen, U. 1992. Molecular Physics. 77(6): 1123-1152.
  4. Experimental and ab initio investigation of the O–H overtone vibration in ethanol  |  Weibel, J. D., Jackels, C. F., & Swofford, R. L. 2002. The Journal of chemical physics. 117(9): 4245-4254.
  5. Raman spectroscopy of 3‐(pent‐1‐enyl) methyl ether and selected deuterium‐labelled analogues  |  Brown, H. C., Bowen, R. D., Edwards, H. G., & Farwell, D. W. 2007. Journal of Raman Spectroscopy: An International Journal for Original Work in all Aspects of Raman Spectroscopy, Including Higher Order Processes, and also Brillouin and Rayleigh Scattering. 38(12): 1586-1594.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethanol-2,2,2-d3, 1 g

sc-227994
1 g
$149.00