Date published: 2025-12-6

1-800-457-3801

SCBT Portrait Logo
Seach Input

Ethambutol Dihydrochloride (CAS 1070-11-7)

0.0(0)
Write a reviewAsk a question

Alternate Names:
2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride
Application:
Ethambutol Dihydrochloride is A tuberculostatic antibacterial
CAS Number:
1070-11-7
Molecular Weight:
277.23
Molecular Formula:
C10H26Cl2N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ethambutol dihydrochloride is widely used in research focused on antimicrobial mechanisms and the resistance patterns of mycobacteria. It is particularly valuable for studies on the inhibition of arabinosyl transferases, enzymes involved in the synthesis of the bacterial cell wall. Researchers use ethambutol dihydrochloride to explore how this inhibition affects bacterial viability and to understand the genetic basis of resistance that bacteria develop against this mechanism. This compound is also used in biochemical assays to examine the interaction between the chemical and its target enzymes, providing detailed insights into chemical-target dynamics. Additionally, ethambutol dihydrochloride is used in studies aiming to develop new strategies to overcome drug resistance.


Ethambutol Dihydrochloride (CAS 1070-11-7) References

  1. [R,S]-Ethambutol dihydrochloride: variable-temperature studies of a dimorphic system with very similar packing.  |  Rubin-Preminger, JM., et al. 2004. J Pharm Sci. 93: 2810-9. PMID: 15452847
  2. Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride.  |  Becker, C., et al. 2008. J Pharm Sci. 97: 1350-60. PMID: 17879380
  3. Screening of bulk drug samples and anti-tuberculosis products for the presence of therapeutically less active diasteriomeric (R,S) form of ethambutol dihydrochloride.  |  Prasad, B., et al. 2008. Indian J Tuberc. 55: 192-8. PMID: 19295106
  4. Precise, fast, and flexible determination of protein interactions by affinity capillary electrophoresis: part 1: performance.  |  Redweik, S., et al. 2012. Electrophoresis. 33: 3316-22. PMID: 22968653
  5. The development of dimple-shaped chitosan carrier for ethambutol dihydrochloride dry powder inhaler.  |  Ahmad, MI., et al. 2015. Drug Dev Ind Pharm. 41: 791-800. PMID: 24694185
  6. The safety of ethambutol dihydrochloride dry powder formulations containing chitosan for the possibility of treating lung tuberculosis.  |  Ahmad, MI., et al. 2014. Inhal Toxicol. 26: 908-17. PMID: 25472479
  7. Transport properties in aqueous ethambutol dihydrochloride.  |  Veríssimo, LM., et al. 2015. Int J Pharm. 479: 306-11. PMID: 25545796
  8. Improved Stability of Tuberculosis Drug Fixed-Dose Combination Using Isoniazid-Caffeic Acid and Vanillic Acid Cocrystal.  |  Battini, S., et al. 2018. J Pharm Sci. 107: 1667-1679. PMID: 29462633
  9. Soft known-value constraints for improved quantitation in multivariate curve resolution.  |  Akbari Lakeh, M., et al. 2020. Anal Chim Acta. 1105: 64-73. PMID: 32138927
  10. Multi-Methodological Quantitative Taste Assessment of Anti-Tuberculosis Drugs to Support the Development of Palatable Paediatric Dosage Forms.  |  Keating, AV., et al. 2020. Pharmaceutics. 12: PMID: 32316692
  11. Chemical characterization of ethambutol binding to Mycobacterium smegmatis.  |  Beggs, WH. and Andrews, FA. 1974. Antimicrob Agents Chemother. 5: 234-9. PMID: 4840434
  12. [Blood level and elimination of ethambutol-dihydrochloride in terminal kidney insufficiency and in hemodialysis].  |  Dume, T., et al. 1971. Verh Dtsch Ges Inn Med. 77: 1022-5. PMID: 5155955
  13. [Determination of ethambutol dihydrochloride in pharmaceutical preparations].  |  Olivari, G. and Pettinari, G. 1970. Boll Chim Farm. 109: 21-4. PMID: 5452991

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethambutol Dihydrochloride, 10 g

sc-207645
10 g
$257.00