Molecular structure of Etanidazole, CAS Number: 22668-01-5
Etanidazole (CAS 22668-01-5)
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Alternate Names:
N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide
CAS Number:
22668-01-5
Molecular Weight:
214.18
Molecular Formula:
C7H10N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Etanidazole is a compound known as a 2-nitroimidazole, which exhibits radiosensitizing properties. By depleting glutathione and inhibiting glutathione transferase, it effectively enhances the cytotoxic effects of ionizing radiation. Etanidazole, derived from ethanolamine, is a monocarboxylic acid amide resulting from the formal condensation of (2-nitro-1H-imidazol-1-yl)acetic acid′s carboxy group with ethanolamine′s amino group.
Etanidazole (CAS 22668-01-5) References
- Hypoxia and etanidazole alter radiation-induced apoptosis in HL60 cells but not in MOLT-4 cells. | Inanami, O., et al. 2002. Int J Radiat Biol. 78: 267-74. PMID: 12020438
- Sustained release of etanidazole from spray dried microspheres prepared by non-halogenated solvents. | Wang, FJ. and Wang, CH. 2002. J Control Release. 81: 263-80. PMID: 12044566
- Effects of fabrication conditions on the characteristics of etanidazole spray-dried microspheres. | Wang, FJ. and Wang, CH. 2002. J Microencapsul. 19: 495-510. PMID: 12396386
- Distribution of etanidazole into human brain tumors: implications for treating high grade gliomas. | Hurwitz, SJ., et al. 1992. Int J Radiat Oncol Biol Phys. 22: 573-6. PMID: 1531216
- Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro. | Jin, C., et al. 2007. Biomaterials. 28: 3724-30. PMID: 17509678
- Technique, pharmacokinetics, toxicity, and efficacy of intratumoral etanidazole and radiotherapy for treatment of spontaneous feline oral squamous cell carcinoma. | Evans, SM., et al. 1991. Int J Radiat Oncol Biol Phys. 20: 703-8. PMID: 1825993
- Effect of pH, oxygenation, and temperature on the cytotoxicity and radiosensitization by etanidazole. | Teicher, BA., et al. 1991. Int J Radiat Oncol Biol Phys. 20: 723-31. PMID: 1825994
- A comparison of radiosensitization by etanidazole and pimonidazole in mouse tumors. | Stone, HB., et al. 1991. Int J Radiat Oncol Biol Phys. 20: 987-95. PMID: 1827089
- Evaluation of the in vivo radiosensitizing activity of etanidazole using tumor-bearing chick embryo. | Abe, C., et al. 2011. J Radiat Res. 52: 208-14. PMID: 21436611
- Etanidazole as a modulator of combined modality therapy in the rat 9l-gliosarcoma. | Teicher, B., et al. 1992. Int J Oncol. 1: 625-30. PMID: 21584591
- Addition of misonidazole, etanidazole, or hyperthermia to treatment with fluosol-DA/carbogen/radiation. | Teicher, BA., et al. 1989. J Natl Cancer Inst. 81: 929-34. PMID: 2525198
- Modification of the aerobic cytotoxicity of etanidazole. | Palayoor, ST., et al. 1994. Int J Radiat Oncol Biol Phys. 29: 289-93. PMID: 8195021
- Effect of BSO and etanidazole on neurofilament degradation in neonatal rat spinal cord cultures. | Palayoor, ST., et al. 1996. Br J Cancer Suppl. 27: S117-21. PMID: 8763862
- Solubility behavior, phase transition, and structure-based nucleation inhibition of etanidazole in aqueous solutions. | Maurin, MB., et al. 1996. Pharm Res. 13: 1401-5. PMID: 8893282
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Etanidazole, 25 mg | sc-499119 | 25 mg | $408.00 |