Estriol 3-sulfate sodium salt (CAS 5150-64-1)

Estriol 3-sulfate sodium salt is a sodium salt form of the sulfated derivative of estriol, one of the primary estrogen metabolites notable for its presence in various biological systems predominantly as an intermediate or end product of steroid metabolism. In research applications, this compound plays a critical role as a tool for investigating estrogenic activity and its regulatory mechanisms, particularly in studies aimed at elucidating the role of estrogens in various physiological processes. The sulfation of estriol, which involves the addition of a sulfate group, significantly alters its solubility and reactivity, thereby making it a valuable analog for probing the transport, recognition, and metabolism of estrogens through different biological pathways. The presence of the sodium ion enhances its solubility in aqueous solutions, facilitating its use in various experimental setups, especially those involving cell cultures and enzymatic assays where the manipulation of hormone levels and their effects on cellular functions are studied.