Estriol 16α-(β-D-glucuronide) (CAS 1852-50-2)

Estriol 16α-(β-D-glucuronide) is a conjugated estrogen metabolite that plays a critical role in the study of estrogen metabolism and its biological effects. This compound is formed through the glucuronidation of estriol, a process catalyzed by the enzyme UDP-glucuronosyltransferase (UGT). Estriol 16α-(β-D-glucuronide) is primarily used in research to investigate the pathways and regulation of estrogen metabolism in various tissues, particularly in the liver and kidney, where glucuronidation occurs extensively. Research applications include studying its role in the modulation of estrogen receptor activity, where it serves as a model compound to understand the interactions between estrogen metabolites and estrogen receptors. Additionally, it is used to explore its impact on gene expression related to estrogen-responsive genes. Estriol 16α-(β-D-glucuronide) is also employed in analytical chemistry to develop and refine detection methods for estrogen metabolites in biological samples, utilizing techniques such as mass spectrometry and high-performance liquid chromatography (HPLC). These studies help explain the pharmacokinetics and pharmacodynamics of estrogen metabolites, contributing to a deeper understanding of their biological roles and potential impacts on cellular processes. Overall, Estriol 16α-(β-D-glucuronide) is a vital tool in biochemical and physiological research focused on estrogen metabolism and function.