Date published: 2026-4-24

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Estradiol Benzoate (CAS 50-50-0)

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Alternate Names:
17β-Estradiol 3-Benzoate
Application:
Estradiol Benzoate is a steroid used for biological research purposes
CAS Number:
50-50-0
Purity:
≥97%
Molecular Weight:
376.49
Molecular Formula:
C25H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock.Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.


Estradiol Benzoate (CAS 50-50-0) References

  1. Estradiol benzoate and progesterone in advanced human-breast cancer.  |  Landau, RL., et al. 1962. JAMA. 182: 632-6. PMID: 12305404
  2. Different doses of estradiol benzoate induce conditioned place preference after paced mating.  |  Corona, R., et al. 2011. Horm Behav. 60: 264-8. PMID: 21712041
  3. Effects of estradiol, progestogens, and of tibolone on breast proliferation and apoptosis.  |  Pompei, LM., et al. 2015. Climacteric. 18: 518-22. PMID: 25830529
  4. Repeated estradiol benzoate treatment protects against the lordosis-inhibitory effects of restraint and prevents effects of the antiprogestin, RU486.  |  Uphouse, L., et al. 2015. Pharmacol Biochem Behav. 137: 1-6. PMID: 26190222
  5. A Mouse Model of Hypospadias Induced by Estradiol Benzoate.  |  He, HG., et al. 2015. Cell Biochem Biophys. 73: 589-92. PMID: 27259297
  6. Effects of Exposure to Estradiol Benzoate or Flutamide at the Weaning Age on Expression of Connexins in the Caudal Epididymis of Adult Rat.  |  Lee, KH. 2016. Dev Reprod. 20: 349-357. PMID: 28144639
  7. The Clinical Follow-Up of Estradiol Benzoate Priming During Induction of Estrus With Cabergoline in Dogs.  |  Mogheiseh, A., et al. 2017. Top Companion Anim Med. 32: 16-19. PMID: 28750784
  8. Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats.  |  Refaie, MMM. and El-Hussieny, M. 2017. Biomed Pharmacother. 95: 223-229. PMID: 28843910
  9. Estradiol benzoate treatment before ovum pick-up increases the number of good quality oocytes retrieved and improves the production of transferable embryos in Japanese Black cattle.  |  Hidaka, T., et al. 2018. Vet Anim Sci. 5: 1-6. PMID: 32734038
  10. Methyl palmitate reversed estradiol benzoate-induced endometrial hyperplasia in female rats.  |  Olowofolahan, AO., et al. 2021. Toxicol Mech Methods. 31: 43-52. PMID: 32967526
  11. Intravaginal administration of estradiol benzoate capsule for estrus synchronization in goats.  |  Matsumoto, S., et al. 2021. J Reprod Dev. 67: 83-88. PMID: 33518696
  12. Drug Repurposing of Itraconazole and Estradiol Benzoate against COVID-19 by Blocking SARS-CoV-2 Spike Protein-Mediated Membrane Fusion.  |  Yang, C., et al. 2021. Adv Ther (Weinh). 4: 2000224. PMID: 33786369
  13. Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis.  |  Taherian, N., et al. 2021. Iran J Basic Med Sci. 24: 256-263. PMID: 33953866
  14. Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro.  |  Lu, D., et al. 2022. Front Pharmacol. 13: 841941. PMID: 35370702
  15. Identification of Estradiol Benzoate as an Inhibitor of HBx Using Inducible Stably Transfected HepG2 Cells Expressing HiBiT Tagged HBx.  |  He, J., et al. 2022. Molecules. 27: PMID: 35956950

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Estradiol Benzoate, 100 mg

sc-205314
100 mg
$37.00

Estradiol Benzoate, 500 mg

sc-205314A
500 mg
$52.00