Molecular structure of Esmolol Hydrochloride, CAS Number: 81161-17-3
Esmolol Hydrochloride (CAS 81161-17-3)
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Alternate Names:
Methyl 3-{4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl}propanoate hydrochloride
Application:
Esmolol Hydrochloride is a β-adrenergic blocker
CAS Number:
81161-17-3
Purity:
≥97%
Molecular Weight:
331.83
Molecular Formula:
C16H25NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Esmolol Hydrochloride is a selective beta-1 adrenergic receptor antagonist. It functions by competitively blocking the beta-1 adrenergic receptors in the heart and vascular smooth muscle. This action results in a decrease in heart rate and contractility, leading to a reduction in cardiac output. Esmolol Hydrochloride′s mechanism of action involves inhibiting the stimulatory effects of the sympathetic nervous system on the heart, thereby reducing the force and rate of cardiac contractions.
Esmolol Hydrochloride (CAS 81161-17-3) References
- Synthesis and evaluation of esmolol prodrugs for transdermal delivery. | Bijaya, G., et al. 2010. Drug Deliv. 17: 532-40. PMID: 20553111
- Stability of esmolol hydrochloride in the presence of aminophylline, bretylium tosylate, heparin sodium, and procainamide hydrochloride. | Schaaf, LJ., et al. 1990. Am J Hosp Pharm. 47: 1567-71. PMID: 2368749
- Stability of esmolol hydrochloride and sodium nitroprusside in intravenous admixtures. | Karnatz, NN., et al. 1989. Am J Hosp Pharm. 46: 101-4. PMID: 2565685
- Prospective randomized study to compare between intravenous dexmedetomidine and esmolol for attenuation of hemodynamic response to endotracheal intubation. | Selvaraj, V. and Manoharan, KR. 2016. Anesth Essays Res. 10: 343-8. PMID: 27212772
- Esmolol hydrochloride: an ultrashort-acting, beta-adrenergic blocking agent. | Angaran, DM., et al. 1986. Clin Pharm. 5: 288-303. PMID: 2871961
- Compatibility of esmolol hydrochloride with morphine sulfate and fentanyl citrate during simulated Y-site administration. | Karnatz, NN., et al. 1988. Am J Hosp Pharm. 45: 368-71. PMID: 2896460
- Visual compatibility of esmolol hydrochloride and various injectable drugs during simulated Y-site injection. | Colucci, RD., et al. 1988. Am J Hosp Pharm. 45: 630-2. PMID: 2897164
- Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts. | Kulkarni, SA., et al. 2022. Front Endocrinol (Lausanne). 13: 926129. PMID: 36082077
- Noradrenergic pathway from the locus coeruleus to heart is implicated in modulating SUDEP. | Lian, X., et al. 2023. iScience. 26: 106284. PMID: 36968083
- Stability of esmolol hydrochloride in 5% dextrose injection. | Wiest, DB., et al. 1995. Am J Health Syst Pharm. 52: 716-8. PMID: 7627740
- Stability of esmolol hydrochloride in intravenous solutions. | Baaske, DM., et al. 1994. Am J Hosp Pharm. 51: 2693-6. PMID: 7856582
- Effect of hypothermia and sampling site on blood esmolol concentrations. | Jacobs, JR., et al. 1993. J Clin Pharmacol. 33: 360-5. PMID: 8097210
- Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity. | Litman, RS. and Zerngast, BA. 1996. J Am Osteopath Assoc. 96: 616-8. PMID: 8936932
Inhibitor of:
beta1-AR, Ces3a, GPR175, MRAP2, Olfr1507, Olfr668, Olfr883, Olfr885, Olfr887, and Reg Iβ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Esmolol Hydrochloride, 10 mg | sc-211424 | 10 mg | $149.00 |