ESD Antibody (H-9): sc-514891

ESD Antibody (H-9) is a mouse monoclonal IgG2a antibody that detects ESD in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ESD, also known as esterase D or S-formylglutathione hydrolase, is a 282 amino acid protein belonging to the esterase D family, predominantly expressed in the placenta, kidney, liver, and erythrocytes, and is localized in the cytoplasm and cytoplasmic vesicles. One of the critical functions of ESD is its role in detoxifying formaldehyde, a harmful compound that can accumulate in the body. ESD achieves this by catalyzing the hydrolysis of S-formylglutathione, a product of formaldehyde oxidation by alcohol dehydrogenase 5, into the reduced forms of formic acid and glutathione, thereby facilitating the safe elimination of formaldehyde and contributing to cellular energy metabolism. Additionally, ESD exhibits carboxylesterase activity, hydrolyzing various neutral ester substrates, and may function as a cysteine hydrolase, although ESD is susceptible to inactivation by thiol alkylating agents. Genetic polymorphisms in the ESD gene can lead to reduced enzymatic activity, which has been associated with an increased risk of several health conditions, including toxic liver cirrhosis, retinoblastoma, obesity, and autism. Anti-ESD antibody (H-9) is an essential tool for researchers studying the biochemical pathways involving formaldehyde detoxification and the implications of ESD in various diseases.

The preferred ESD antibody is ESD Antibody (A-5): sc-514892.