ESC Antibody (F-6): sc-390300

ESC Antibody (F-6) is a mouse monoclonal IgM kappa antibody that detects ESC protein of Drosophila melanogaster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ESC antibody (F-6) is available as the non-conjugated form. Extra Sex Combs (ESC) protein plays a crucial role in regulating gene expression during early development by mediating transcriptional silencing through the Polycomb-group (Pc-G) complex. ESC protein is essential for maintaining proper expression of homeotic genes, which are responsible for segment identity in Drosophila. ESC protein interacts with other key proteins, such as Enhancer of zeste (E(z)), which directly binds to ESC and is integral to Pc-G complex formation. Such interaction is vital for recruiting the complex to Polycomb Response Elements, ensuring silencing of regulatory genes throughout development. Proper functioning of ESC and associated proteins is critical for correct developmental processes, and any dysregulation can lead to significant developmental abnormalities.

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ESC Antibody (F-6) References:

1. Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein.  |  O'Connell, S., et al. 2001. J Biol Chem. 276: 43065-73. PMID: 11571280
2. corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae.  |  Lopez, A., et al. 2001. Mol Genet Genomics. 266: 572-83. PMID: 11810228
3. Identification of putative interaction partners for the Xenopus Polycomb-group protein Xeed.  |  Showell, C. and Cunliffe, VT. 2002. Gene. 291: 95-104. PMID: 12095683
4. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.  |  Czermin, B., et al. 2002. Cell. 111: 185-96. PMID: 12408863
5. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.  |  van Lohuizen, M., et al. 1998. Mol Cell Biol. 18: 3572-9. PMID: 9584197

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ESC Antibody (F-6) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ESC Antibody (F-6) Specifications

Alternate Product Name: ESC

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 11-49

Epitope Target: ESC

Epitope Species: Drosophila melanogaster

Product Reactivity/Detection: ESC

Species Reactivity/Detection: d

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ESC Antibody (F-6): P: Blocking Peptide