ES-D3 Whole Cell Lysate: sc-364776

ES-D3 whole cell lysate is derived from the ES-D3 cell line, an embryonic stem cell line from mice, predominantly used in developmental biology and regenerative medicine research to understand stem cell differentiation and pluripotency mechanisms. This lysate provides critical insights into the signaling pathways that regulate stem cell fate, such as the Wnt, Notch, and BMP pathways, which are crucial for maintaining stem cell characteristics or driving differentiation into various cell types. Researchers utilize ES-D3 lysate to explore how these cells respond to different biochemical signals and the intrinsic mechanisms that control gene expression during cell differentiation processes. It's especially useful in examining the role of transcription factors like Oct4, Sox2, and Nanog, which are pivotal in maintaining the pluripotent state. Additionally, this lysate allows for the study of cellular responses to external stimuli that mimic developmental cues, providing a model for understanding early embryonic development and potential applications in disease modeling. By using ES-D3 lysate, scientists aim to explain the complex molecular interactions that govern cell behavior in developmental biology, strictly within a research context, contributing to a broader understanding of cellular development processes.

ES-D3 Whole Cell Lysate References:

1. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery.  |  Ratajczak, J., et al. 2006. Leukemia. 20: 847-56. PMID: 16453000
2. Androgenic and antiandrogenic effects and expression of androgen receptor in mouse embryonic stem cells.  |  Chang, CY., et al. 2006. Fertil Steril. 85 Suppl 1: 1195-203. PMID: 16616092