Erythromycin Ethylsuccinate (CAS 41342-53-4)

Erythromycin Ethylsuccinate, identified by CAS number 41342-53-4, is an ester derivative of the parent compound erythromycin, a well-known macrolide antibiotic. This derivative is distinguished by its ethylsuccinate ester group, which enhances its solubility and stability, making it particularly useful in various research applications. Like its parent compound, erythromycin ethylsuccinate functions by binding to the 50S ribosomal subunit in bacterial cells, thereby inhibiting the process of protein synthesis. This action is specifically targeted at the translocation step, where it impedes the movement of the ribosome along messenger RNA (mRNA), thus blocking the elongation of protein chains and effectively halting bacterial growth. In the scientific community, this compound has been utilized extensively to investigate the mechanisms of action of macrolides at the molecular level, particularly in understanding how modifications to the erythromycin structure impact its interaction with bacterial ribosomes. Additionally, it has been employed in studies aimed at probing the resistance mechanisms of bacteria to macrolide antibiotics, helping researchers to identify genetic mutations that confer resistance and to explore strategies to overcome these defense mechanisms. This research is crucial for advancing the field of microbiology and developing new approaches to manage bacterial infections effectively.