Molecular structure of Erythromycin, CAS Number: 114-07-8
Erythromycin (CAS 114-07-8)
See product citations (4)
Alternate Names:
Abomacetin
Application:
Erythromycin is a macrolide antibiotic protein synthesis inhibitor
CAS Number:
114-07-8
Purity:
≥92%
Molecular Weight:
733.93
Molecular Formula:
C37H67NO13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Erythromycin is a compound extensively studied in microbiological research due to its interaction with bacterial ribosomes. The focus of research on erythromycin often centers on its role in inhibiting bacterial protein synthesis by binding to the 50S subunit of the ribosome, which is a key step in the translation process. This action makes it an important tool for investigating the mechanisms of protein synthesis in prokaryotic organisms. In molecular biology, erythromycin is used to study the effects of ribosomal inhibition on bacterial growth and gene expression. It is also utilized in the exploration of bacterial resistance mechanisms, as the compound can serve as a selective pressure in the laboratory, leading to the emergence of resistance through various genetic alterations. Additionally, erythromycin is employed in the field of synthetic biology for the regulation of gene expression systems, where it can act as an inducer or repressor in genetically engineered constructs.
Erythromycin (CAS 114-07-8) References
- Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban. | Tran, JQ., et al. 1999. J Clin Pharmacol. 39: 513-9. PMID: 10234600
- Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells. | Aoki, Y. and Kao, PN. 1999. Antimicrob Agents Chemother. 43: 2678-84. PMID: 10543746
- Determination of erythromycin and related substances in enteric-coated tablet formulations by reversed-phase liquid chromatography. | Wardrop, J., et al. 2000. J Pharm Sci. 89: 1097-105. PMID: 10944374
- Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism. | Tokairin, T., et al. 2005. Br J Clin Pharmacol. 60: 172-5. PMID: 16042670
- Erythromycin as a prokinetic agent: risk factors. | Berthet, S., et al. 2010. J Visc Surg. 147: e13-8. PMID: 20655290
- Autobacteriographic studies of clarithromycin and erythromycin in mice. | Kohno, Y., et al. 1990. Antimicrob Agents Chemother. 34: 562-7. PMID: 2140497
- Concentrations of erythromycin, 2'-acetyl erythromycin, and their anhydro forms in plasma and tonsillar tissue after repeated dosage of erythromycin stearate and erythromycin acistrate. | Gordin, A., et al. 1988. Antimicrob Agents Chemother. 32: 1019-24. PMID: 3190191
- Determination of 2'-acetyl erythromycin and erythromycin in human tonsil tissue by HPLC with coulometric detection. | Haataja, H. and Kokkonen, P. 1988. J Antimicrob Chemother. 21 Suppl D: 67-72. PMID: 3391877
- Erythromycin lactobionate: pharmacokinetics and uterine tissue levels. | Segui, A., et al. 1987. Eur J Drug Metab Pharmacokinet. 12: 153-60. PMID: 3436337
- Gastrointestinal side effects with erythromycin preparations. | Carter, BL., et al. 1987. Drug Intell Clin Pharm. 21: 734-8. PMID: 3498618
- Penetration of erythromycin in respiratory tract infections. | Walstad, RA. and Hellum, KB. 1984. Acta Otolaryngol Suppl. 407: 50-4. PMID: 6333775
- Inducible erythromycin resistance in bacteria. | Weisblum, B. 1984. Br Med Bull. 40: 47-53. PMID: 6442874
- Inhibitory action of erythromycin on bacteriophage SPO1 multiplication in sporulating cells of Bacillus subtilis 168. | Hirochika, H. 1980. Mol Gen Genet. 179: 581-8. PMID: 6777627
- Improved high-pressure liquid chromatographic method for the analysis of erythromycin in solid dosage forms. | Tsuji, K. and Kane, MP. 1982. J Pharm Sci. 71: 1160-4. PMID: 7143216
- Combinatorial biosynthesis of erythromycin and complex polyketides. | Staunton, J. 1998. Curr Opin Chem Biol. 2: 339-45. PMID: 9691072
Inhibitor of:
2610528E23Rik, AlaRS, APIP, Aspartoacylase-3, ATP-binding cassette (ABC) transporter, Bordetella, Bordetella pertussis, Brucella abortus LPS, BSEP, Chlamydia LPS, CLC-3, CRS4C-5, cryptdin 22, cryptdin 3, Cyclosporin A, CYP2D12, CYP2D40, CYP39A1, CYP3A, CYP3A1, Cyp3a11, Cyp3a13, Cyp3a18, Cyp3a25, CYP3A4, CYP3A43, CYP3A5, CYP3A7-CYP3AP1, CYP4F3, CYP4V2, Cyp60, CYPOR, cytochrome b5 type B, DaRS, DHRS4, Diphtheria Toxin, Dynein IC2, EF-Ts, EG665562, Enrofloxacin, Erwinia herbicola, exonucleasefamily surface anchored protein, FK-506, Francisella tularensis LPS, GTPBP5, H. influenzae B, HNP-1, hnRNP A2/B1, HSP 65, ICT1, IleRS, Legionella pneumophila LPS, LHFPL5, megalin, MRP-63, MRP-L1, MRP-L19, MRP-L20, MRP-L33, MRP-L46, MRP-L47, MRP-L54, MRP-S22, mt-TyrRS, Mycoplasma, OATP-B, OATP-C, OATP-D, OATP-E, OATP-F, OATP-H, OATP-J, OATP16, Oatp2, OATP2A1, Oatp3, Oatp4, Oatp5, OATP8, PDE1B, Phosphotransacetylase, RARα2, Ribosomal Protein L28, Ribosomal Protein L29, Ribosomal Protein L36aL, Ribosomal Protein L38, Ribosomal Protein LP1, Ribosomal Protein S12, Ribosomal Protein S13, Ribosomal Protein S14, Ribosomal Protein S15a, Ribosomal Protein S16, Ribosomal Protein S20, Ribosomal Protein S27, Ribosomal Protein S28, Ribosome (RPL; 40S; 60S), RMND1, RPL39L, RPS2, RPS4Y1, RPS4Y2, RPS4YX, rRNA, Salmonella (Enterobacterales), Salmonella O, SBDS, Slco6c1, Slco6d1, Small Proline-Rich Protein (SPRR), Streptococcus agalactiae, Streptococcus Group B, T2R06, T2R42, TaR, TARSL1, TFPI, and WARS2.Activator of:
ASB-15, AsnRS, ATP8B5, Brucella abortus, CYP2D11, CYP3A7-CYP3AP1, FKBP12.6, Glycodelin, H. influenzae B, IF3, LysRS, motilin, MRP-L22, MRP-L30, MRP-S18B, MRP-S25, OATP-A, OATP-J, Oatp-Y, OATP16, PA, ProRS, Rab 4B, Ribosomal Protein L12, Ribosomal Protein L22, Ribosomal Protein L23, Ribosomal Protein L38, Ribosomal Protein L39, Ribosomal Protein L6, Ribosomal Protein S2, Ribosomal Protein S26, Ribosomal Protein S3, Ribosomal Protein S3A, Ribosomal Protein S9, SerRS, SLC41A3, SNX1A, T2R04, T2R14, T2R40, T2R41, T2R42, T2R43, T2R44, T2R7, and T2R8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Erythromycin, 5 g | sc-204742 | 5 g | $56.00 | |||
Erythromycin, 25 g | sc-204742A | 25 g | $240.00 | |||
Erythromycin, 100 g | sc-204742B | 100 g | $815.00 | |||
Erythromycin, 1 kg | sc-204742C | 1 kg | $1305.00 |