Erythroid lineage Antibody (TER-119): sc-19592

Erythroid lineage Antibody (TER-119) is a rat monoclonal IgG2b antibody that detects the Erythroid lineage protein of mouse origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Erythroid lineage antibody (TER-119) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Erythrocytes, the primary target of Erythroid lineage (TER-119) antibody, are crucial for oxygen transport throughout the body, as they contain hemoglobin, a protein that binds oxygen in the lungs and releases it in tissues. The structure of erythrocytes, characterized by their unique 7-8 µm bi-concave disc shape, is essential for maximizing surface area and facilitating efficient gas exchange. Additionally, mature erythrocytes lack a nucleus and mitochondria, which allows for more space to accommodate hemoglobin but also means they rely on anaerobic metabolism for ATP production. This structural adaptation is vital for their primary function, as it enables erythrocytes to transport oxygen effectively without consuming the oxygen they carry. In a healthy human, erythrocyte counts typically range from 4 to 6 million per cubic millimeter of blood, underscoring their importance in maintaining physiological oxygen levels in tissues.

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Erythroid lineage Antibody (TER-119) References:

1. Aging and innate immune cells.  |  Plackett, TP., et al. 2004. J Leukoc Biol. 76: 291-9. PMID: 15039467
2. Chemokine receptors and leukocyte trafficking in the mucosal immune system.  |  Williams, IR. 2004. Immunol Res. 29: 283-92. PMID: 15181289
3. In vivo imaging of leukocyte trafficking in blood vessels and tissues.  |  Mempel, TR., et al. 2004. Curr Opin Immunol. 16: 406-17. PMID: 15245733
4. Interactions between the innate immune and blood coagulation systems.  |  Esmon, CT. 2004. Trends Immunol. 25: 536-42. PMID: 15364056
5. Chemokines: control of primary and memory T-cell traffic.  |  Schaerli, P. and Moser, B. 2005. Immunol Res. 31: 57-74. PMID: 15591623
6. Immune traffic: a functional overview.  |  Beilhack, A. and Rockson, SG. 2003. Lymphat Res Biol. 1: 219-34. PMID: 15624439
7. Leukocyte adhesion: what's the catch?  |  Hammer, DA. 2005. Curr Biol. 15: R96-9. PMID: 15694300
8. Biology of red cells: non-nucleated erythrocytes as fluid drop-like cell fragments.  |  Schmid-Schönbein, H., et al. 1984. Int J Microcirc Clin Exp. 3: 161-96. PMID: 6386726

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Erythroid lineage Antibody (TER-119) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Erythroid lineage Antibody (TER-119) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Erythroid lineage Antibody (TER-119) Specifications

Alternate Product Name: Erythroid lineage

Product Clone Name: TER-119

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Erythroid lineage

Epitope Species: mouse

Product Reactivity/Detection: the cells of the erythroid lineage in embryonic yolk sac, fetal liver, adult bone marrow, adult peripheral blood and adult lymphoid organs; is a component of the lineage cocktail used in studies of hematopoietic progenitors to detect or deplete cells committed to the hematopoietic lineages

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Erythroid lineage Antibody (TER-119): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin